The merit of proton magnetic resonance spectroscopy in the longitudinal assessment of spinocerebellar ataxias and multiple system atrophy-cerebellar type
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  • 作者:Hung-Chieh Chen ; Jiing-Feng Lirng ; Bing-Wen Soong ; Wan Yuo Guo…
  • 关键词:Proton MRS ; SARA ; Spinocerebellar ataxias ; Multiple system atrophy ; cerebellar type
  • 刊名:Cerebellum & Ataxias
  • 出版年:2014
  • 出版时间:December 2014
  • 年:2014
  • 卷:1
  • 期:1
  • 全文大小:1092KB
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  • 作者单位:Hung-Chieh Chen (1) (2)
    Jiing-Feng Lirng (1) (3)
    Bing-Wen Soong (4) (5)
    Wan Yuo Guo (1) (3)
    Hsiu-Mei Wu (1) (3)
    Clayton Chi-Chang Chen (1) (2)
    Cheng-Yen Chang (1) (3)

    1. Department of Radiology, National Yang-Ming University School of Medicine, Taipei, Taiwan
    2. Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan
    3. Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan
    4. Department of Neurology, National Yang-Ming University School of Medicine and Taipei Veterans General Hospital, 155, Sec. 2, Linung St, Taipei, Taiwan
    5. Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan
  • 刊物类别:Neurobiology; Neurosciences; Neurology; Neurosurgery;
  • 刊物主题:Neurobiology; Neurosciences; Neurology; Neurosurgery;
  • 出版者:BioMed Central
  • ISSN:2053-8871
文摘
Background Spinocerebellar ataxia (SCA) and multiple system atrophy-cerebellar type (MSA-C) often present with similar clinical manifestations in the beginning. Magnetic resonance spectroscopy (MRS) has been proved to be a useful tool to help differentiate different types of SCA and MSA-C on cross-sectional studies. However, longitudinal changes of the MRS metabolites in these subjects have never been reported. The purpose of this study was to track the longitudinal evolution of the MRS metabolites in these patients and to ascertain the correlation between clinical severity measured by Scale of the Assessment and Rating of Ataxia (SARA) and MRS metabolites.

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