BPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model
详细信息 查看全文
- 作者：Chien-Chih Chiu ; Han-Lin Chou ; Bing-Hung Chen ; Kuo-Feng Chang ; Chih-Hua Tseng…
- 关键词：Indeno[1 ; 2 ; c]quinolinequinoline ; BPIQ ; Lung cancer ; Apoptosis ; Polyploidy ; Zebrafish xenograft
- 刊名：BMC Cancer
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：2,393 KB
- 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2407
文摘
Background 2,9-Bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy] phenyl}-11H-indeno[1,2-c]quinolin-11-one (BPIQ) is a derivative from 6-arylindeno[1,2-c]quinoline. Our previous study showed the anti-cancer potential of BPIQ compared to its two analogues topotecan and irinotecan. In the study, the aim is to investigate the potency and the mechanism of BPIQ against lung cancer cells.