Transition from inflammation to proliferation: a critical step during wound healing
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- 作者：Ning Xu Landén ; Dongqing Li ; Mona Ståhle
- 关键词：Macrophage ; Fibroblast ; Bioactive lipid mediator ; Reactive oxygen species ; Toll ; like receptor ; Transcription factor ; MicroRNA
- 刊名：Cellular and Molecular Life Sciences (CMLS)
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：73
- 期：20
- 页码：3861-3885
- 全文大小：1,900 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Cell Biology
Biomedicine
Life Sciences
Biochemistry - 出版者：Birkh盲user Basel
- ISSN：1420-9071
- 卷排序：73
文摘
The ability to rapidly restore the integrity of a broken skin barrier is critical and is the ultimate goal of therapies for hard-to-heal-ulcers. Unfortunately effective treatments to enhance healing and reduce scarring are still lacking. A deeper understanding of the physiology of normal repair and of the pathology of delayed healing is a prerequisite for the development of more effective therapeutic interventions. Transition from the inflammatory to the proliferative phase is a key step during healing and accumulating evidence associates a compromised transition with wound healing disorders. Thus, targeting factors that impact this phase transition may offer a rationale for therapeutic development. This review summarizes mechanisms regulating the inflammation–proliferation transition at cellular and molecular levels. We propose that identification of such mechanisms will reveal promising targets for development of more effective therapies.