Admission levels of asymmetric and symmetric dimethylarginine predict long-term outcome in patients with community-acquired pneumonia

详细信息    查看全文

• 作者：Alaadin Vögeli ; Manuel Ottiger ; Marc A. Meier ; Christian Steuer…
• 关键词：Asymmetric dimethylarginine (ADMA) ; Community ; acquired pneumonia (CAP) ; Biomarker ; L ; arginine ; Mortality prediction ; Symmetric dimethylarginine (SDMA)
• 刊名：Respiratory Research
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：678KB
• 刊物主题：Pneumology/Respiratory System;
• 出版者：BioMed Central
• ISSN：1465-993X
• 卷排序：18

文摘

BackgroundDuring infection, there is an activation of the L-arginine-nitric-oxide pathway, with a shift from nitric oxide synthesis to a degradation of L-arginine to its metabolites, asymmetric and symmetric dimethylarginine (ADMA and SDMA). However, the prognostic implications for short-term or long-term survival remains unclear. We investigated the association of L-arginine, ADMA, and SDMA with adverse clinical outcomes in a well-defined cohort of patients with community-acquired pneumonia (CAP).