Optimization of bone scaffold structures using experimental and numerical data

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• 作者：Przemysław Makowski ; Wacław Kuś
• 刊名：Acta Mechanica
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：227
• 期：1
• 页码：139-149
• 全文大小：2,757 KB
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• 作者单位：Przemysław Makowski (1)
  Wacław Kuś (1)
  
  1. Institute of Computational Mechanics and Engineering, Silesian University of Technology, Gliwice, Poland
  
• 刊物类别：Engineering
• 刊物主题：Theoretical and Applied Mechanics
  Mechanics, Fluids and Thermodynamics
  Continuum Mechanics and Mechanics of Materials
  Structural Mechanics
  Vibration, Dynamical Systems and Control
  Engineering Thermodynamics and Transport Phenomena
  
• 出版者：Springer Wien
• ISSN：1619-6937

文摘

Optimization of bone scaffold structures is performed on the basis of homogenized orthotropic elastic properties of trabecular bone tissue and three-scale numerical model. The orthotropic effective material properties are calculated using a finite element method numerical model of bone microstructure with numerical homogenization algorithm and serve as a template of surgically removed bone tissue. The evolutionary algorithm is used to optimize patient-specific, periodic structure of the bone scaffold, possessing parameters similar to the removed bone and so allowing the bone tissue to heal and rebuild faster. The proposed methodology can be used to design bone scaffolds manufactured from biodegradable biopolymers using fused deposition modeling methods.