The effectiveness of opioid substitution treatments for patients with opioid dependence: a systematic review and multiple treatment comparison protocol
详细信息    查看全文
  • 作者：Brittany Burns Dennis (1) (2)
    Leen Naji (3)
    Monica Bawor (2) (4)
    Ashley Bonner (1)
    Michael Varenbut (5)
    Jeff Daiter (5)
    Carolyn Plater (5)
    Guillaume Pare (1) (9)
    David C Marsh (5) (6)
    Andrew Worster (5) (7)
    Dipika Desai (2) (9)
    Zainab Samaan (1) (2) (8) (9)
    Lehana Thabane (1) (10) (11) (12) (9)

    1. Department of Clinical Epidemiology and Biostatistics     ; McMaster University ; Hamilton ; Canada
    2. Population Genomic Program     ; Chanchlani Research Centre ; McMaster University ; Hamilton ; Canada
    3. Michael G. DeGroote School of Medicine     ; McMaster University ; Hamilton ; Canada
    4. McMaster Integrative Neuroscience Discovery & Study (MiNDS) Program     ; McMaster University ; Hamilton ; Canada
    5. Ontario Addiction Treatment Centres     ; Richmond Hill ; Canada
    9. Population Health Research Institute     ; Hamilton Health Sciences ; Hamilton ; Canada
    6. Northern Ontario School of Medicine     ; Sudbury ; ON ; Canada
    7. Department of Medicine     ; Hamilton General Hospital ; Hamilton ; Canada
    8. Department of Psychiatry and Behavioral Neurosciences     ; McMaster University ; Hamilton ; Canada
    10. Department of Pediatrics and Anesthesia     ; McMaster University ; Hamilton ; Canada
    11. Centre for Evaluation of Medicine     ; St Joseph鈥檚 Healthcare鈥擧amilton ; Hamilton ; Canada
    12. Biostatistics Unit     ; Father Sean O鈥橲ullivan Research Centre ; St Joseph鈥檚 Healthcare鈥擧amilton ; 3rd Floor ; Martha Wing ; Room H-325 ; 50 Charlton Avenue East ; Hamilton ; ON ; L8N 4A6 ; Canada
  • 关键词：Opioid substitution therapies ; Opioid dependence ; Methadone ; Buprenorphine/naloxone ; Naltrexone ; Heroin ; Systematic review ; Network meta ; analysis
  • 刊名：Systematic Reviews
  • 出版年：2014
  • 出版时间：December 2014
  • 年：2014
  • 卷：3
  • 期：1
  • 全文大小：776 KB
  • 参考文献：1. Franklin, GM, Rahman, EA, Turner, JA, Daniell, WE, Fulton-Kehoe, D (2009) Opioid use for chronic low back pain: A prospective, population-based study among injured workers in Washington state, 2002-2005. Clin J Pain 25: pp. 743-751 CrossRef
    2. Webster, PC (2012) Medically induced opioid addiction reaching alarming levels. CMAJ 184: pp. 285-286 CrossRef
    3. Association, AP (2013) Diagnostic and statistical manual of mental disorders. American Psychiatric Publishing, Arlington, VA
    4. Gugelmann, HM, Perrone, J (2011) Can prescription drug monitoring programs help limit opioid abuse?. JAMA 306: pp. 2258-2259 12" target="_blank" title="It opens in new window">CrossRef
    5. Sproule, B, Brands, B, Li, S, Catz-Biro, L (2009) Changing patterns in opioid addiction: characterizing users of oxycodone and other opioids. Can Fam Physician 55: pp. 68-69
    6. Nicholls, L, Bragaw, L, Ruetsch, C (2010) Opioid dependence treatment and guidelines. J Manag Care Pharm 16: pp. S14-S21
    7. Dhalla, IA, Mamdani, MM, Sivilotti, ML, Kopp, A, Qureshi, O, Juurlink, DN (2009) Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone. CMAJ 181: pp. 891-896 CrossRef
    8. National Vital Statistics System (WONDER) http://wonder.cdc.gov/
    9. CfDCa, P (2013) Policy impact: prescription painkiller overdoses. USA, Atlanta
    10. Chong, E, Poh, KK, Shen, L, Yeh, IB, Chai, P (2009) Infective endocarditis secondary to intravenous Subutex abuse. Singap Med J 50: pp. 34-42
    11. Ho, RC, Ho, EC, Tan, CH, Mak, A (2009) Pulmonary hypertension in first episode infective endocarditis among intravenous buprenorphine users: case report. Am J Drug Alcohol Abuse 35: pp. 199-202 CrossRef
    12. Zhang, L, Zhang, D, Chen, W, Zou, X, Ling, L (2013) High prevalence of HIV, HCV and tuberculosis and associated risk behaviours among new entrants of methadone maintenance treatment clinics in Guangdong Province. China PLoS One 8: pp. e76931 CrossRef
    13. / Methadone maintenance treatment program standards and clinical guidelines 4th edition. Toronto, Canada: The College of Physicians and Surgeons of Ontario; 2011.
    14. The world health report 2002 鈥?Reducing Risks, Promoting Healthy Life http://www.who.int/whr/2002/en/
    15. Ezzati, M, Lopez, AD, Rodgers, A, Vander Hoorn, S, Murray, CJ (2002) Selected major risk factors and global and regional burden of disease. Lancet 360: pp. 1347-1360 CrossRef
    16. Metzger, DS, Woody, GE, McLellan, AT, O'Brien, CP, Druley, P, Navaline, H, DePhilippis, D, Stolley, P, Abrutyn, E (1993) Human immunodeficiency virus seroconversion among intravenous drug users in- and out-of-treatment: an 18-month prospective follow-up. J Acquir Immune Defic Syndr 6: pp. 1049-1056
    17. Zou, S, Tepper, M, Giulivi, A (2000) Current status of hepatitis C in Canada. Can J Public Health 91: pp. S10-S15
    18. Wall, R, Rehm, J, Fischer, B, Brands, B, Gliksman, L, Stewart, J, Medved, W, Blake, J (2000) Social costs of untreated opioid dependence. J Urban Health 77: pp. 688-722 CrossRef
    19. Oppenheimer, E, Tobutt, C, Taylor, C, Andrew, T (1994) Death and survival in a cohort of heroin addicts from London clinics: a 22-year follow-up study. Addiction 89: pp. 1299-1308 CrossRef
    20. Seal, KH, Kral, AH, Gee, L, Moore, LD, Bluthenthal, RN, Lorvick, J, Edlin, BR (2001) Predictors and prevention of nonfatal overdose among street-recruited injection heroin users in the San Francisco Bay Area, 1998-1999. Am J Public Health 91: pp. 1842-1846 CrossRef
    21. Coutinho, RA (1998) HIV and hepatitis C among injecting drug users. BMJ 317: pp. 424-425 CrossRef
    22. Li, Y, Kantelip, JP, Gerritsen-van Schieveen, P, Davani, S (2008) Interindividual variability of methadone response: impact of genetic polymorphism. Mol Diagn Ther 12: pp. 109-124 CrossRef
    23. Crettol, S, Monnat, M, Eap, CB (2007) Could pharmacogenetic data explain part of the interindividual sensitivity to methadone-induced respiratory depression?. Crit Care 11: pp. 119 CrossRef
    24. Eap, CB, Buclin, T, Baumann, P (2002) Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence. Clin Pharmacokinet 41: pp. 1153-1193 CrossRef
    25. Eap, CB, Bertschy, G, Baumann, P, Finkbeiner, T, Gastpar, M, Scherbaum, N (1998) High interindividual variability of methadone enantiomer blood levels to dose ratios. Arch Gen Psychiatry 55: pp. 89-90 CrossRef
    26. Yang, F, Tong, X, McCarver, DG, Hines, RN, Beard, DA (2006) Population-based analysis of methadone distribution and metabolism using an age-dependent physiologically based pharmacokinetic model. J Pharmacokinet Pharmacodyn 33: pp. 485-518 CrossRef
    27. Fischer, B, Chin, AT, Kuo, I, Kirst, M, Vlahov, D (2002) Canadian illicit opiate users' views on methadone and other opiate prescription treatment: an exploratory qualitative study. Subst Use Misuse 37: pp. 495-522 120002807" target="_blank" title="It opens in new window">CrossRef
    28. Simon-Sanchez, J, Singleton, AB (2008) Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls. Hum Mol Genet 17: pp. 1988-1993 CrossRef
    29. Mendelson, J, Jones, RT, Welm, S, Baggott, M, Fernandez, I, Melby, AK, Nath, RP (1999) Buprenorphine and naloxone combinations: the effects of three dose ratios in morphine-stabilized, opiate-dependent volunteers. Psychopharmacology (Berl) 141: pp. 37-46 CrossRef
    30. Bell, J, Byron, G, Gibson, A, Morris, A (2004) A pilot study of buprenorphine-naloxone combination tablet (Suboxone) in treatment of opioid dependence. Drug Alcohol Rev 23: pp. 311-317 12331289473" target="_blank" title="It opens in new window">CrossRef
    31. Orman, JS, Keating, GM (2009) Buprenorphine/naloxone: a review of its use in the treatment of opioid dependence. Drugs 69: pp. 577-607 CrossRef
    32. Whelan, PJ, Remski, K (2012) Buprenorphine vs methadone treatment: A review of evidence in both developed and developing worlds. J Neurosci Rural Pract 3: pp. 45-50 CrossRef
    33. Curcio, F, Franco, T, Topa, M, Baldassarre, C (2011) Buprenorphine/naloxone versus methadone in opioid dependence: a longitudinal survey. Eur Rev Med Pharmacol Sci 15: pp. 871-874
    34. Sullivan, MA, Bisaga, A, Mariani, JJ, Glass, A, Levin, FR, Comer, SD, Nunes, EV (2013) Naltrexone treatment for opioid dependence: does its effectiveness depend on testing the blockade?. Drug Alcohol Depend 133: pp. 80-85 CrossRef
    35. FDA approves Perjeta for neoadjuvant breast cancer treatment http://www.fda.gov/newsevents/newsroom/pressannouncements/ucm370393.htm
    36. Comer, SD, Sullivan, MA, Yu, E, Rothenberg, JL, Kleber, HD, Kampman, K, Dackis, C, O'Brien, CP (2006) Injectable, sustained-release naltrexone for the treatment of opioid dependence: a randomized, placebo-controlled trial. Arch Gen Psychiatry 63: pp. 210-218 CrossRef
    37. Krupitsky, E, Zvartau, E, Woody, G (2010) Use of naltrexone to treat opioid addiction in a country in which methadone and buprenorphine are not available. Curr Psychiatry Rep 12: pp. 448-453 CrossRef
    38. Gibson, AE, Degenhardt, LJ (2007) Mortality related to pharmacotherapies for opioid dependence: a comparative analysis of coronial records. Drug Alcohol Rev 26: pp. 405-410 CrossRef
    39. Oviedo-Joekes, E, Brissette, S, Marsh, DC, Lauzon, P, Guh, D, Anis, A, Schechter, MT (2009) Diacetylmorphine versus methadone for the treatment of opioid addiction. N Engl J Med 361: pp. 777-786 CrossRef
    40. Nosyk, B, Guh, DP, Bansback, NJ, Oviedo-Joekes, E, Brissette, S, Marsh, DC, Meikleham, E, Schechter, MT, Anis, AH (2012) Cost-effectiveness of diacetylmorphine versus methadone for chronic opioid dependence refractory to treatment. CMAJ 184: pp. E317-E328 CrossRef
    41. Cohen, J (1960) A coefficient of agreement for nominal scales. Educ Psychol Meas 20: pp. 37-46 CrossRef
    42. Stroup, DFBJ, Morton, SC, Olkin, I, Williamson, GD, Rennie, D (2000) Meta-analysis of Observational Studies in Epidemiology. JAMA 283: pp. 2008-2012 CrossRef
    43. Moher, D, Liberati, A, Tetzlaff, J, Altman, DG (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8: pp. 336-341 CrossRef
    44. Wells GA, SB, O鈥機onnell, D, Peterson, J, Welch, V, Losos, M (2009) The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses.
    45. Research Projects: Cochrane Risk of Bias tool http://bmg.cochrane.org/research-projectscochrane-risk-bias-tool
    46. Hser, YI, Anglin, D, Powers, K (1993) A 24-year follow-up of California narcotics addicts. Arch Gen Psychiatry 50: pp. 577-584 CrossRef
    47. Maas, J, Barton, G, Maskrey, V, Pinto, H, Holland, R (2013) Economic evaluation: A comparison of methadone versus buprenorphine for opiate substitution treatment. Drug Alcohol Depend 133: pp. 494-501 CrossRef
    48. Mattick, RP, Ali, R, White, JM, O'Brien, S, Wolk, S, Danz, C (2003) Buprenorphine versus methadone maintenance therapy: a randomized double-blind trial with 405 opioid-dependent patients. Addiction (Abingdon, England) 98: pp. 441-452 CrossRef
    49. Samaan, Z, Bawor, M, Dennis, B, Plater, C, Worster, A, Varenbut, M, Daiter, J, Marsh, DC, Desai, D, Thabane, L, Pare, G (2014) Genetic influence in methadone dose and response to treatment in patients undergoing Methadone Maintenance Treatment (MMT) for opioid addiction: A pilot study. J Neuropsychiatr Dis Treat.
    50. Fudala, PJ, Bridge, TP, Herbert, S, Williford, WO, Chiang, CN, Jones, K, Collins, J, Raisch, D, Casadonte, P, Goldsmith, RJ, Malkerneker, U, McNicholas, L, Renner, J, Stine, S, Tusel, D (2003) Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone. N Engl J Med 349: pp. 949-958 CrossRef
    51. Ling, W, Amass, L, Shoptaw, S, Annon, JJ, Hillhouse, M, Babcock, D, Brigham, G, Harrer, J, Reid, M, Muir, J, Buchan, B, Orr, D, Woody, G, Kreici, J, Ziedonis, D (2005) A multi-center randomized trial of buprenorphine-naloxone versus clonidine for opioid detoxification: findings from the National Institute on Drug Abuse Clinical Trials Network. Addiction 100: pp. 1090-1100 CrossRef
    52. Hser, YI, Saxon, AJ, Huang, D, Hasson, A, Thomas, C, Hillhouse, M, Jacobs, P, Teruya, C, McLaughlin, P, Wiest, K, Cohen, A, Ling, W (2014) Treatment retention among patients randomized to buprenorphine/naloxone compared to methadone in a multi-site trial. Addiction 109: pp. 79-87 12333" target="_blank" title="It opens in new window">CrossRef
    53. Deck, D, Carlson, MJ (2005) Retention in publicly funded methadone maintenance treatment in two Western States. J Behav Health Serv Res 32: pp. 43-60 CrossRef
    54. Apelt, SM, Scherbaum, N, Golz, J, Backmund, M, Soyka, M (2013) Safety, effectiveness and tolerance of buprenorphine-naloxone in the treatment of opioid dependence: results from a nationwide non-interventional study in routine care. Pharmacopsychiatry 46: pp. 94-107 CrossRef
    55. Concato, J, Shah, N, Horwitz, RI (2000) Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 342: pp. 1887-1892 CrossRef
    56. Benson, K, Hartz, AJ (2000) A comparison of observational studies and randomized, controlled trials. N Engl J Med 342: pp. 1878-1886 CrossRef
    57. Higgins JPT, Green S (Eds): The Cochrane Collaboration In / The Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 2011.
    58. Navarese, EP, Kozinski, M, Pafundi, T, Andreotti, F, Buffon, A, Servi, SD, Kubica, J (2011) Practical and updated guidelines on performing meta-analyses of non-randomized studies in interventional cardiology. Cardiol J 18: pp. 3-7
    59. Knapp, G, Hartung, J (2003) Improved tests for a random effects meta-regression with a single covariate. Stat Med 22: pp. 2693-2710 CrossRef
    60. R: RDCT: R: A language for statistical computing. / Vienna R Foundation for Statistical Computing
    61. Cornell, JE, Mulrow, CD, Localio, R, Stack, CB, Meibohm, AR, Guallar, E, Goodman, SN (2014) Random-effects meta-analysis of inconsistent effects: a time for change. Ann Intern Med 160: pp. 267-270 CrossRef
    62. DerSimonian, R, Kacker, R (2007) Random-effects model for meta-analysis of clinical trials: an update. Contemp Clin Trials 28: pp. 105-114 CrossRef
    63. Mills, EJ, Ioannidis, JP, Thorlund, K, Schunemann, HJ, Puhan, MA, Guyatt, GH (2012) How to use an article reporting a multiple treatment comparison meta-analysis. JAMA 308: pp. 1246-1253 12.jama.11228" target="_blank" title="It opens in new window">CrossRef
    64. Silva, PS, Reis, ME, Aguiar, VE, Fonseca, MC (2013) Unplanned extubation in the neonatal ICU: a systematic review, critical appraisal, and evidence-based recommendations. Respir Care 58: pp. 1237-1245 CrossRef
    65. Lumley, T (2002) Network meta-analysis for indirect treatment comparisons. Stat Med 21: pp. 2313-2324 1201" target="_blank" title="It opens in new window">CrossRef
    66. Veroniki, AA, Vasiliadis, HS, Higgins, JP, Salanti, G (2013) Evaluation of inconsistency in networks of interventions. Int J Epidemiol 42: pp. 332-345 CrossRef
    67. Higgins, J (2013) Identifying and addressing inconsistency in network meta-analysis. Cochrane Comparing Multiple Interventions Methods Group Oxford Training Event: 2013.
    68. Dias, S, Welton, NJ, Caldwell, DM, Ades, AE (2010) Checking consistency in mixed treatment comparison meta-analysis. Stat Med 29: pp. 932-944 CrossRef
    69. Salanti, G, Ades, AE, Ioannidis, JP (2011) Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial. J Clin Epidemiol 64: pp. 163-171 CrossRef
    70. Guyatt, G, Oxman, AD, Akl, EA, Kunz, R, Vist, G, Brozek, J, Norris, S, Falck-Ytter, Y, Glasziou, P, DeBeer, H, Jaeschke, R, Rind, D, Meerpohl, J, Dahm, P, Sch眉nemann, HJ (2011) GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol 64: pp. 383-394 CrossRef
    71. Guyatt, GH, Oxman, AD, Kunz, R, Woodcock, J, Brozek, J, Helfand, M, Alonso-Coello, P, Falck-Ytter, Y, Jaeschke, R, Vist, G, Akl, EA, Post, PN, Norris, S, Meerpohl, J, Shukla, VK, Nasser, M, Sch眉nemann, HJ (2011) GRADE guidelines: 8. Rating the quality of evidence鈥攊ndirectness. J Clin Epidemiol 64: pp. 1303-1310 CrossRef
  • 刊物主题：Medicine/Public Health, general; Biomedicine general; Statistics for Life Sciences, Medicine, Health Sciences;
  • 出版者：BioMed Central
  • ISSN：2046-4053
文摘
Background Opioids are psychoactive analgesic drugs prescribed for pain relief and palliative care. Due to their addictive potential, effort and vigilance in controlling prescriptions is needed to avoid misuse and dependence. Despite the effort, the prevalence of opioid use disorder continues to rise. Opioid substitution therapies are commonly used to treat opioid dependence; however, there is minimal consensus as to which therapy is most effective. Available treatments include methadone, heroin, buprenorphine, as well as naltrexone. This systematic review aims to assess and compare the effect of all available opioid substitution therapies on the treatment of opioid dependence. Methods/Design The authors will search Medline, EMBASE, PubMed, PsycINFO, Web of Science, Cochrane Library, Cochrane Clinical Trials Registry, World Health Organization International Clinical Trials Registry Platform Search Portal, and the National Institutes for Health Clinical Trials Registry. The title, abstract, and full-text screening will be completed in duplicate. When appropriate, multiple treatment comparison Bayesian meta-analytic methods will be performed to deduce summary statistics estimating the effectiveness of all opioid substitution therapies in terms of retention and response to treatment (as measured through continued opioid abuse). Discussion Using evidence gained from this systematic review, we anticipate disseminating an objective review of the current available literature on the effectiveness of all opioid substitution therapies for the treatment of opioid use disorder. The results of this systematic review are imperative to the further enhancement of clinical practice in addiction medicine. Systematic review registration PROSPERO CRD42013006507.

© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号

地址：北京市海淀区学院路29号 邮编：100083

电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700