Confidence bands for the difference between two median survival times as a function of covariates
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- 作者：Yuh-Ing Chen (1)
Yu-Mei Chang (2)
Jen-Yu Lee (3)
1. Institute of Statistics ; National Central University ; Jhongli ; 320 ; Taiwan ; ROC
2. Department of Statistics ; Tunghai University ; Taichung ; 407 ; Taiwan ; ROC
3. Biostatistics Center ; Taipei Medical University ; Taipei ; 110 ; Taiwan ; ROC - 关键词：Confidence band ; Median survival time ; Right ; censored data ; Stratified Cox model ; Treatment ; specific Cox model
- 刊名：Lifetime Data Analysis
- 出版年：2015
- 出版时间：January 2015
- 年：2015
- 卷：21
- 期：1
- 页码：97-118
- 全文大小：397 KB
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- 刊物主题：Statistics
Statistics
Statistics for Life Sciences, Medicine and Health Sciences
Quality Control, Reliability, Safety and Risk
Statistics for Business, Economics, Mathematical Finance and Insurance
Operation Research and Decision Theory - 出版者：Springer Netherlands
- ISSN：1572-9249
文摘
In this paper, the estimation of the difference between two median survival times is considered when two treatment groups of right-censored data and the associated covariates are available. To identify the possible range of covariates over which the two treatments would produce different median survival times, two confidence bands for the difference as a function of the covariates are proposed under the stratified and treatment-specific Cox models, respectively. The results of a simulation study indicate that the latter generally maintains its confidence level and the former holds its confidence level and preserves a narrower width when the two treatments satisfy the stratified Cox model. An application of the proposed confidence bands is finally illustrated with a data set in a two-arm lung cancer study.