Circadian mRNA expression: insights from modeling and transcriptomics
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- 作者：Sarah Lück ; Pål O. Westermark
- 关键词：Circadian ; mRNA expression ; Post ; transcriptional regulation ; Systems biology ; Biostatistics
- 刊名：Cellular and Molecular Life Sciences (CMLS)
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：73
- 期：3
- 页码：497-521
- 全文大小：1,278 KB
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Pål O. Westermark (1)
1. Institute for Theoretical Biology, Charité – Universitätsmedizin Berlin, Invalidenstrasse 43, 10115, Berlin, Germany - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Cell Biology
Biomedicine
Life Sciences
Biochemistry - 出版者：Birkh盲user Basel
- ISSN：1420-9071
文摘
Circadian clocks synchronize organisms to the 24 h rhythms of the environment. These clocks persist under constant conditions, have their origin at the cellular level, and produce an output of rhythmic mRNA expression affecting thousands of transcripts in many mammalian cell types. Here, we review the charting of circadian output rhythms in mRNA expression, focusing on mammals. We emphasize the challenges in statistics, interpretation, and quantitative descriptions that such investigations have faced and continue to face, and outline remaining outstanding questions. Keywords Circadian mRNA expression Post-transcriptional regulation Systems biology Biostatistics