Exploring diurnal variation using piecewise linear splines: an example using blood pressure

详细信息    查看全文

• 作者：Jamie M. Madden ; Xia Li ; Patricia M. Kearney…
• 关键词：Circadian modeling ; Mixed ; effects models ; Biostatistics ; Blood pressure variability ; Blood pressure patterns
• 刊名：Emerging Themes in Epidemiology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：14
• 期：1
• 全文大小：1801KB
• 刊物主题：Epidemiology; Public Health;
• 出版者：BioMed Central
• ISSN：1742-7622
• 卷排序：14

文摘

BackgroundThere are many examples of physiological processes that follow a circadian cycle and researchers are interested in alternative methods to illustrate and quantify this diurnal variation. Circadian blood pressure (BP) deserves additional attention given uncertainty relating to the prognostic significance of BP variability in relation to cardiovascular disease. However, the majority of studies exploring variability in ambulatory blood pressure monitoring (ABPM) collapse the data into single readings ignoring the temporal nature of the data. Advanced statistical techniques are required to explore complete variation over 24 h.