Neuroprotective effect of Reseda luteola L. extract in a mouse neuronal cell model

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• 作者：Seong Soon Kim (1)
  Ji Yeon Seo (1)
  Soon Sung Lim (2)
  Hwa Jin Suh (3)
  Lione Kim (4)
  Jong-Sang Kim (1)
  
  1. School of Food Science and Biotechnology ; Kyungpook National University ; Daegu ; 702-701 ; Korea
  2. Department of Food Science and Nutrition ; Hallym University ; Chuncheon ; Gangwon ; 200-702 ; Korea
  3. Gyeongbuk Natural Color Industry Institute ; Youngcheon ; Gyeongbuk ; 770-060 ; Korea
  4. Whasoomok Company ; Yeongcheon ; Gyeongbuk ; 770-831 ; Korea
  
• 关键词：Reseda luteola L ; neuroprotection ; luteolin
• 刊名：Food Science and Biotechnology
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：24
• 期：1
• 页码：333-339
• 全文大小：523 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nutrition
  Food Science
  
• 出版者：The Korean Society of Food Science and Technology in co-publication with Springer
• ISSN：2092-6456

文摘

Aqueous extracts of Reseda luteola L. used as a dyeing agent for centuries have antioxidant activities. The neuroprotective effect of aqueous herb extracts were investigated against glutamate-induced reactive oxygen species (ROS) insult using mouse hippocampal HT22 and cortical neural cells. Aqueous extracts and the hexane fraction of R. luteola L. effectively attenuated the cytotoxicity of glutamate (5 mM) in both HT22 and primary neural cells derived from the mouse cortex. The neuroprotective effect was attributable to unidentified components and luteolin, which is known as a biologically active constituent. Aqueous extracts of R. luteola L. deserve further study for identification of active components and development of food colorants with health benefits.