Apoptotic signal pathways and regulatory mechanisms of cancer cells induced by IL-24

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• 作者：Huilin Liu ; Jiaojiao Chen ; Xingyan Jiang…
• 关键词：Key wordsapoptosis ; IL ; 24 ; signal pathway ; tumor
• 刊名：Wuhan University Journal of Natural Sciences
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：21
• 期：6
• 页码：519-530
• 全文大小：592 KB
• 刊物类别：Mathematics and Statistics
• 刊物主题：Mathematics
  Computer Science, general
  Physics
  Life Sciences
  Chinese Library of Science
  
• 出版者：Wuhan University, co-published with Springer
• ISSN：1993-4998
• 卷排序：21

文摘

The melanoma differentiation-associated gene-7(mda-7), IL-24, has the specific functions that induce cancer cell apoptosis without doing harm to normal cells. We systematically review the apoptotic signal pathways and their regulatory mechanisms induced by Ad.IL-24 and IL-24 in diverse cancer cells. IL-24 can participate in varied signal transduction pathways, including JAK, p38 MAPK, Wnt/β-catenin, JNK, ER stress and mitochondria-associated signal pathways. And we review five proteins interacting with IL-24, including Bip/GRP78, S1R, PKR, Beclin1 and soluble clusterin, which are relative to the tumor-specific effect of IL-24. It is speculated that ER stress, G-protein pathways and MAPK signal pathways may be the primary upstream effectors which activate the sequential downstream mediators resulting in apoptosis induced by IL-24 in tumor cells. Experimental results also show that IL-24 sensitizes cancer cells and indirectly promotes apoptosis rather than functions as a direct apoptosis inducer itself.