Synthesis of biscoumarin and dihydropyran derivatives as two novel classes of potential anti-bacterial derivatives
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- 作者：Jing Li ; Xiao-yan Xue ; Xia Li ; Zheng Hou ; Xiao-hui Yang…
- 关键词：Bisoumarin ; Dihydropyran ; Antibacterial ; DFT
- 刊名：Archives of Pharmacal Research
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：39
- 期：10
- 页码：1349-1355
- 全文大小：602 KB
- 刊物主题：Pharmacy; Pharmacology/Toxicology;
- 出版者：Springer Netherlands
- ISSN：1976-3786
- 卷排序：39
文摘
A series of bisoumarin (1–4) and dihydropyran (5–8) derivatives were successfully synthesized as new antibacterial agents. The molecular structures of three representative compounds 1, 5 and 7 were confirmed by single crystal X-ray diffraction study. Among these compounds tested toward Staphylococcus aureus (S. aureus ATCC 29213), methicillin-resistant S. aureus (MRSA XJ 75302), vancomycin-intermediate S. aureus (Mu50 ATCC 700699), and USA 300 (Los Angeles County clone, LAC), compounds 1 and 2 displayed the most potent antibacterial activity. Additionally, the HB energy in biscoumarins 1–4 was calculated by density functional theory (DFT) [B3LYP/6-31G*] method.