Adrenergic gene polymorphisms and cardiovascular risk in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation

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• 作者：Michael A Pacanowski (1)
  Issam Zineh (1)
  Haihong Li (2)
  B Delia Johnson (3)
  Rhonda M Cooper-DeHoff (4)
  Vera Bittner (5)
  Dennis M McNamara (6)
  Barry L Sharaf (7)
  C Noel Bairey Merz (8)
  Carl J Pepine (4)
  Julie A Johnson (1)
  
• 刊名：Journal of Translational Medicine
• 出版年：2008
• 出版时间：December 2008
• 年：2008
• 卷：6
• 期：1
• 全文大小：438KB
• 参考文献：1. Rosamond W, Flegal K, Friday G, Furie K, Go A, Greenlund K, Haase N, Ho M, Howard V, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell C J, Roger V, Rumsfeld J, Sorlie P, Steinberger J, Thom T, Wasserthiel-Smoller S, Hong Y: Heart Disease and Stroke Statistics--2007 Update. A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. / Circulation 2006.
  2. Sharaf BL, Pepine CJ, Kerensky RA, Reis SE, Reichek N, Rogers WJ, Sopko G, Kelsey SF, Holubkov R, Olson M, Miele NJ, Williams DO, Merz CN: Detailed angiographic analysis of women with suspected ischemic chest pain (pilot phase data from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation [WISE] Study Angiographic Core Laboratory). / Am J Cardiol 2001,87(8):937-1; A3. CrossRef
  3. Panting JR, Gatehouse PD, Yang GZ, Grothues F, Firmin DN, Collins P, Pennell DJ: Abnormal Subendocardial Perfusion in Cardiac Syndrome X Detected by Cardiovascular Magnetic Resonance Imaging. / N Engl J Med 2002,346(25):1948-953. CrossRef
  4. Buchthal SD, den Hollander JA, Merz CN, Rogers WJ, Pepine CJ, Reichek N, Sharaf BL, Reis S, Kelsey SF, Pohost GM: Abnormal myocardial phosphorus-31 nuclear magnetic resonance spectroscopy in women with chest pain but normal coronary angiograms. / N Engl J Med 2000,342(12):829-35. CrossRef
  5. Quyyumi AA: Women and ischemic heart disease: pathophysiologic implications from the Women's Ischemia Syndrome Evaluation (WISE) Study and future research steps. / J Am Coll Cardiol 2006,47(3 Suppl):S66-1. CrossRef
  6. Johnson BD, Shaw LJ, Buchthal SD, Bairey Merz CN, Kim HW, Scott KN, Doyle M, Olson MB, Pepine CJ, den Hollander J, Sharaf B, Rogers WJ, Mankad S, Forder JR, Kelsey SF, Pohost GM: Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). / Circulation 2004,109(24):2993-999. CrossRef
  7. Sesso HD, Lee IM, Gaziano JM, Rexrode KM, Glynn RJ, Buring JE: Maternal and paternal history of myocardial infarction and risk of cardiovascular disease in men and women. / Circulation 2001,104(4):393-98. CrossRef
  8. Cambien F, Tiret L: Genetics of cardiovascular diseases: from single mutations to the whole genome. / Circulation 2007,116(15):1714-724. CrossRef
  9. Lanfear DE, Jones PG, Marsh S, Cresci S, McLeod HL, Spertus JA: Beta2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndrome. / Jama 2005,294(12):1526-533. CrossRef
  10. Beitelshees AL, Gong Y, Wang D, Schork NJ, Cooper-Dehoff RM, Langaee TY, Shriver MD, Sadee W, Knot HJ, Pepine CJ, Johnson JA: KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST). / Pharmacogenet Genomics 2007,17(9):719-29. CrossRef
  11. Lanfear DE, Jones PG, Marsh S, Cresci S, Spertus JA, McLeod HL: Connexin37 (GJA4) genotype predicts survival after an acute coronary syndrome. / Am Heart J 2007,154(3):561-66. CrossRef
  12. Schuit SC, Oei HH, Witteman JC, Geurts van Kessel CH, van Meurs JB, Nijhuis RL, van Leeuwen JP, de Jong FH, Zillikens MC, Hofman A, Pols HA, Uitterlinden AG: Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction. / Jama 2004,291(24):2969-977. CrossRef
  13. Kirstein SL, Insel PA: Autonomic Nervous System Pharmacogenomics: A Progress Report. / Pharmacol Rev 2004,56(1):31-2. CrossRef
  14. Bairey Merz CN, Kelsey SF, Pepine CJ, Reichek N, Reis SE, Rogers WJ, Sharaf BL, Sopko G, for the WSG: The Women's Ischemia Syndrome Evaluation (WISE) Study: protocol design, methodology and feasibility report. / J Am Coll Cardiol 1999,33(6):1453-461. CrossRef
  15. Stephens M, Scheet P: Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation. / Am J Hum Genet 2005,76(3):449-62. CrossRef
  16. Ruczinski I, Kooperberg C, LeBlanc M: Logic regression. / Journal of Computational and Graphical Statistics 2003,12(3):475-11. CrossRef
  17. Kooperberg C, Bis JC, Marciante KD, Heckbert SR, Lumley T, Psaty BM: Logic regression for analysis of the association between genetic variation in the renin-angiotensin system and myocardial infarction or stroke. / Am J Epidemiol 2007,165(3):334-43. CrossRef
  18. The Comprehensive R Archive Network [cran.r-project.org]
  19. Kip KE, Marroquin OC, Shaw LJ, Arant CB, Wessel TR, Olson MB, Johnson BD, Mulukutla S, Sopko G, Merz CN, Reis SE: Global inflammation predicts cardiovascular risk in women: a report from the Women's Ischemia Syndrome Evaluation (WISE) study. / Am Heart J 2005,150(5):900-06. CrossRef
  20. Mason DA, Moore JD, Green SA, Liggett SB: A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. / J Biol Chem 1999,274(18):12670-2674. CrossRef
  21. Iwai C, Akita H, Kanazawa K, Shiga N, Terashima M, Matsuda Y, Takai E, Miyamoto Y, Shimizu M, Kajiya T, Hayashi T, Yokoyama M: Arg389Gly polymorphism of the human beta1-adrenergic receptor in patients with nonfatal acute myocardial infarction. / Am Heart J 2003,146(1):106-09. CrossRef
  22. Mialet Perez J, Rathz DA, Petrashevskaya NN, Hahn HS, Wagoner LE, Schwartz A, Dorn GW, Liggett SB: Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure. / Nat Med 2003,9(10):1300-305. CrossRef
  23. White HL, Maqbool A, McMahon AD, Yates L, Ball SG, Hall AS, Balmforth AJ: An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals at risk of coronary events. A WOSCOPS substudy. / Eur Heart J 2002,23(14):1087-092. CrossRef
  24. Akhter SA, D'Souza KM, Petrashevskaya NN, Mialet-Perez J, Liggett SB: Myocardial beta1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury. / Am J Physiol Heart Circ Physiol 2006,290(4):H1427-2. CrossRef
  25. Pietri-Rouxel F, St John Manning B, Gros J, Strosberg AD: The biochemical effect of the naturally occurring Trp64-->Arg mutation on human beta3-adrenoceptor activity. / Eur J Biochem 1997,247(3):1174-179. CrossRef
  26. Higashi K, Ishikawa T, Ito T, Yonemura A, Shige H, Nakamura H: Association of a genetic variation in the beta 3-adrenergic receptor gene with coronary heart disease among Japanese. / Biochem Biophys Res Commun 1997,232(3):728-30. CrossRef
  27. Morrison AC, Brancati FL, Folsom AR, Smith L, Boerwinkle E: Beta3-adrenergic receptor Trp64Arg polymorphism does not predict incident CHD or carotid intima-media thickness in a community-based sample of whites: the ARIC study. Atherosclerosis Risk in Communities. / Hum Genet 1999,105(4):314-19. CrossRef
  28. Stangl K, Cascorbi I, Laule M, Stangl V, Meisel C, Wernecke KD, Ziemer S, Baumann G, Roots I, Hauner H: The beta3-adrenergic receptor Trp64Arg mutation is not associated with coronary artery disease. / Metabolism 2001,50(2):184-88. CrossRef
  29. Zafarmand MH, van der Schouw YT, Grobbee DE, de Leeuw PW, Bots ML: T64A polymorphism in beta3-adrenergic receptor gene (ADRB3) and coronary heart disease: a case-cohort study and meta-analysis. / J Intern Med 2008,263(1):79-9. CrossRef
  30. Rozec B, Gauthier C: beta3-adrenoceptors in the cardiovascular system: putative roles in human pathologies. / Pharmacol Ther 2006,111(3):652-73. CrossRef
  31. Terra SG, McGorray SP, Wu R, McNamara DM, Cavallari LH, Walker JR, Wallace MR, Johnson BD, Bairey Merz CN, Sopko G, Pepine CJ, Johnson JA: Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study. / Int J Obes (Lond) 2005,29(7):746-54. CrossRef
  32. Dessy C, Moniotte S, Ghisdal P, Havaux X, Noirhomme P, Balligand JL: Endothelial beta3-adrenoceptors mediate vasorelaxation of human coronary microarteries through nitric oxide and endothelium-dependent hyperpolarization. / Circulation 2004,110(8):948-54. CrossRef
  33. Steinle JJ, Booz GW, Meininger CJ, Day JN, Granger HJ: Beta 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation. / J Biol Chem 2003,278(23):20681-0686. CrossRef
  34. Reis SE, Holubkov R, Conrad Smith AJ, Kelsey SF, Sharaf BL, Reichek N, Rogers WJ, Merz CN, Sopko G, Pepine CJ: Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study. / Am Heart J 2001,141(5):735-41. CrossRef
  
• 作者单位：Michael A Pacanowski (1)
  Issam Zineh (1)
  Haihong Li (2)
  B Delia Johnson (3)
  Rhonda M Cooper-DeHoff (4)
  Vera Bittner (5)
  Dennis M McNamara (6)
  Barry L Sharaf (7)
  C Noel Bairey Merz (8)
  Carl J Pepine (4)
  Julie A Johnson (1)
  
  1. Department of Pharmacy Practice and Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, FL, USA
  2. Department of Epidemiology and Health Policy Research, University of Florida College of Medicine, Gainesville, FL, USA
  3. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA
  4. Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA
  5. Department of Medicine, University of Alabama Birmingham, Birmingham, A, USA
  6. Department of Medicine, University of Pittsburgh Graduate School of Medicine, Pittsburgh, PA, USA
  7. Department of Medicine, Rhode Island Hospital, Providence, RI, USA
  8. Department of Medicine and Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
  

文摘

Background Adrenergic gene polymorphisms are associated with cardiovascular and metabolic phenotypes. We investigated the influence of adrenergic gene polymorphisms on cardiovascular risk in women with suspected myocardial ischemia. Methods We genotyped 628 women referred for coronary angiography for eight polymorphisms in the α1A-, β1-, β2- and β3-adrenergic receptors (ADRA1A, ADRB1, ADRB2, ADRB3, respectively), and their signaling proteins, G-protein β 3 subunit (GNB3) and G-protein α subunit (GNAS). We compared the incidence of death, myocardial infarction, stroke, or heart failure between genotype groups in all women and women without obstructive coronary stenoses. Results After a median of 5.8 years of follow-up, 115 women had an event. Patients with the ADRB1 Gly389 polymorphism were at higher risk for the composite outcome due to higher rates of myocardial infarction (adjusted hazard ratio [HR] 3.63, 95% confidence interval [95%CI] 1.17-1.28; Gly/Gly vs. Arg/Arg HR 4.14, 95%CI 0.88-9.6). The risk associated with ADRB1 Gly389 was limited to those without obstructive CAD (n = 400, Pinteraction = 0.03), albeit marginally significant in this subset (HR 1.71, 95%CI 0.91-.19). Additionally, women without obstructive CAD carrying the ADRB3 Arg64 variant were at higher risk for the composite endpoint (HR 2.10, 95%CI 1.05-.24) due to subtle increases in risk for all of the individual endpoints. No genetic associations were present in women with obstructive CAD. Conclusion In this exploratory analysis, common coding polymorphisms in the β1- and β3-adrenergic receptors increased cardiovascular risk in women referred for diagnostic angiography, and could improve risk assessment, particularly for women without evidence of obstructive CAD. Trial Registration ClinicalTrials.gov NCT00000554.