Disparate metabolic effects of blackcurrant seed oil in rats fed a basal and obesogenic diet

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• 作者：Adam Jurgoński ; Bartosz Fotschki ; Jerzy Ju?kiewicz
• 关键词：Blackcurrant seed oil ; Essential fatty acids ; Lipid metabolism ; Liver function ; Caecum ; Rats
• 刊名：European Journal of Nutrition
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：54
• 期：6
• 页码：991-999
• 全文大小：423 KB
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• 作者单位：Adam Jurgoński (1)
  Bartosz Fotschki (1)
  Jerzy Ju?kiewicz (1)
  
  1. Division of Food Science, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10 Tuwima Street, 10-748, Olsztyn, Poland
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nutrition
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1436-6215

文摘

Purpose It was hypothesised that blackcurrant seed oil beneficially modulates metabolic disorders related to obesity and its complications. The study also aimed to investigate the potentially adverse effects of an unbalanced diet on the distal intestine. Methods Male Wistar rats were randomly assigned to four groups of eight animals each and were fed a basal or obesogenic (high in fat and low in fibre) diet that contained either rapeseed oil (Canola) or blackcurrant seed oil. A two-way analysis of variance was then applied to assess the effects of diet and oil and the interaction between them. Results After 8?weeks, the obesogenic dietary regimen increased the body weight, altered the plasma lipid profile and increased the liver fat content and the plasma transaminase activities. In addition, the obesogenic diet decreased bacterial glycolytic activity and short-chain fatty acid formation in the distal intestine. Dietary blackcurrant seed oil improved the lipid metabolism by lowering liver fat accumulation and the plasma triglyceride concentration and atherogenicity as well by increasing the plasma HDL-cholesterol concentration. However, in rats fed an obesogenic diet containing blackcurrant seed oil, the plasma HDL-cholesterol concentration was comparable with both rapeseed oil-containing diets, and a significant elevation of the plasma transaminase activities was noted instead. Conclusions The obesogenic dietary regimen causes a number of metabolic disorders, including alterations in the hindgut microbial metabolism. Dietary blackcurrant seed oil ameliorates the lipid metabolism; however, the beneficial effect is restricted when it is provided together with the obesogenic diet, and a risk of liver injury may occur.