Muscle free amino acid profiles are related to differences in skeletal muscle growth between single and twin ovine fetuses near term

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• 作者：Francisco Sales ; David Pacheco ; Hugh Blair ; Paul Kenyon ; Sue McCoard
• 关键词：Free amino acid ; Fetal muscle ; Gestation ; Muscle growth ; Sheep
• 刊名：SpringerPlus
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：2
• 期：1
• 全文大小：250KB
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• 作者单位：Francisco Sales (5) (6) (8)
  David Pacheco (5)
  Hugh Blair (6) (7)
  Paul Kenyon (6) (7)
  Sue McCoard (5) (6)
  
  5. Animal Nutrition Team, Animal Nutrition and Health Group, AgResearch, Grasslands Research Centre, Palmerston North, New Zealand
  6. Gravida: National Research Centre for Growth and Development, Auckland, New Zealand
  8. Instituto de Investigaciones Agropecuarias, Centro Regional Kampenaike, Punta Arenas, Chile
  7. Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand
  
• 刊物类别：Science, general;
• 刊物主题：Science, general;
• 出版者：Springer International Publishing
• ISSN：2193-1801

文摘

Twin sheep fetuses have reduced skeletal muscle weight near birth relative to singles as a result of restricted muscle hypertrophy. Intracellular free amino acids (FAA) are reported to regulate metabolic pathways which control muscle protein accretion, whereby reduced intracellular content of specific FAA may reduce their activation and therefore, muscle hypertrophy. The aim of this study was to determine whether differences in muscle weight between singleton and twin fetuses, under different maternal conditions is associated with reduced concentration of specific FAA. The FAA content in the semitendinosus muscle (ST) in singleton and twin fetuses (rank) at 140 days of gestation from heavy (H) or light (L) ewes fed ad libitum (A) or maintenance (M) level of nutrition was measured. Muscle weight was reduced in twin fetuses compared to singletons in all groups. Reduced concentrations of leucine, threonine and valine, but higher concentrations of methionine, ornithine, lysine and serine were found in twin fetuses compared to singletons. Maternal size and nutrition interaction with rank resulted in reduced glutamine in twins from HM-ewes (H-ewes under M nutrition) compared to their singleton counterparts. Maternal weight interaction with pregnancy rank reduced the concentration of arginine in twins, with a larger effect on H-ewes compared with L-ewes. Maternal size interaction with pregnancy rank resulted in twins from M-ewes to have lower alanine, while twins from A-ewes had lower aspartic acid concentration compared to singletons. The ST muscle weight was positively correlated only with arginine concentration after taking into account rank, size and nutrition. The present results indicate that reduced concentrations of specific intracellular FAA, such as arginine, leucine, valine, glutamine, which are known to play a role in muscle growth, could be acting as limiting factors for muscle hypertrophy in twin fetuses during late gestation. Ewe size and nutrition can influence the concentration of specific FAA in muscle and should be considered in any intervention plan to improve twin fetal muscle growth. Keywords Free amino acid Fetal muscle Gestation Muscle growth Sheep