Acid suppression therapy and allergic reactions
详细信息 查看全文
- 作者：Eva Untersmayr MD ; PhD
- 关键词：gastric acid suppression medication ; proton pump inhibitors ; H2 receptor blockers ; food allergy ; drug allergy ; sensitization
- 刊名：Allergo Journal
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：24
- 期：8
- 页码：25-33
- 全文大小：523 KB
- 参考文献：1.Henn RM, Isenberg JI, Maxwell V, Sturdevant RAL. Inhibition of Gastric Acid Secretion by Cimetidine in Patients with Duodenal Ulcer. N Engl J Med 1975;293:371–5PubMed CrossRef
2.Blum AL, Bethge H, Bode JC, Domschke W, Feurle G, Hackenberg K, et al. Sucralfate in the treatment and prevention of gastric ulcer: multicentre double blind placebo controlled study. Gut 1990;31:825–30PubMed PubMedCentral CrossRef
3.Borella LE, Seethaler K, Lippmann W. Sucralfate: antipeptic, antiulcer activities and antagonism of gastric emptying. Arzneimittelforschung 1979;29:793–8PubMed
4.Olbe L, Carlsson E, Lindberg P. A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole. Nat Rev Drug Discov 2003;2:132–9PubMed CrossRef
5.Andersson T. Pharmacokinetics, metabolism and interactions of acid pump inhibitors. Focus on omeprazole, lansoprazole and pantoprazole. Clin Pharmacokinet 1996;31:9–28PubMed CrossRef
6.www.medscape.com/viewarticle/820011 (last accessed 15.04.2015)
7.www.forbes.com/sites/simonking/2013/01/28/the-best-selling-drugs-of-all-time-humira-joins-the-elite/ (last accessed 15.04.2015)
8.Thomson AB, Sauve MD, Kassam N, Kamitakahara H. Safety of the long-term use of proton pump inhibitors. World J Gastroenterol 2010;16:2323–30PubMed PubMedCentral CrossRef
9.Glew CM, Rentler RJ. Use of proton pump inhibitors and other acid suppressive medications in newly admitted nursing facility patients. J Am Med Dir Assoc 2007;8:607–9PubMed CrossRef
10.Ruchi Gupta MD, Praveen Garg MD, Ravi Kottoor MD, Juan Carlos Munoz MD, M. Mazen Jamal MD, Louis RLMD, et al. Overuse of Acid Suppression Therapy in Hospitalized Patients. South Med J 2010;103:207–11PubMed CrossRef
11.Corder AP, Jones RH, Sadler GH, Daniels P, Johnson CD. Heartburn, oesophagitis and Barrett’s oesophagus in self-medicating patients in general practice. Br J Clin Pract 1996;50:245–8PubMed
12.Feurle GE. Effect of rising intragastric pH induced by several antacids on serum gastrin concentrations in duodenal ulcer patients and in a control group. Gastroenterology 1975;68:1–7PubMed
13.Ogawa R, Echizen H. Clinically significant drug interactions with antacids: an update. Drugs 2011;71:1839–64PubMed CrossRef
14.Samloff IM, O’Dell C. Inhibition of peptic activity by sucralfate. Am J Med 1985;79:15–8PubMed CrossRef
15.Venables CW. Mucus, pepsin, and peptic ulcer. Gut 1986; 27:233–8PubMed PubMedCentral CrossRef
16.McCarthy DM. Sucralfate. N Engl J Med 1991;325:1017–25PubMed CrossRef
17.Nagashima R. Mechanisms of action of sucralfate. J Clin Gastroenterol 1981;3:117–27PubMed
18.Slomiany BL, Piotrowski J, Okazaki K, Grzelinska E, Slomiany A. Nature of the enhancement of the protective qualities of gastric mucus by sucralfate. Digestion 1989;44:222–31PubMed CrossRef
19.Fisher RS. Sucralfate: a review of drug tolerance and safety. J Clin Gastroenterol 1981;3:181–4PubMed
20.Ishimori A. Safety experience with sucralfate in Japan. J Clin Gastroenterol 1981;3:169–73PubMed
21.Marks IN. The efficacy, safety and dosage of sucralfate in ulcer therapy. Scand J Gastroenterol Suppl 1987;140:33–8PubMed
22.Aihara T, Nakamura E, Amagase K, Tomita K, Fujishita T, Furutani K, et al. Pharmacological control of gastric acid secretion for the treatment of acid-related peptic disease: past, present, and future. Pharmacol Ther 2003;98:109–27PubMed CrossRef
23.Rossing MA, Scholes D, Cushing-Haugen KL, Voigt LF. Cimetidine use and risk of prostate and breast cancer. Cancer Epidemiol Biomarkers Prev 2000;9:319–23PubMed
24.Rendic S. Drug interactions of H2-receptor antagonists involving cytochrome P450 (CYPs) enzymes: from the laboratory to the clinic. Croat Med J 1999;40:357–67PubMed
25.Fellenius E, Berglindh T, Sachs G, Olbe L, Elander B, Sjostrand SE, et al. Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase. Nature 1981;290:159–61PubMed CrossRef
26.Lindberg P, Nordberg P, Alminger T, Brandstrom A, Wallmark B. The mechanism of action of the gastric acid secretion inhibitor omeprazole. J Med Chem 1986;29:1327–9PubMed CrossRef
27.Wallmark B, Larsson H, Humble L. The relationship between gastric acid secretion and gastric H+,K+-ATPase activity. J Biol Chem 1985;260:13681–4PubMed
28.Robinson M. Proton pump inhibitors: update on their role in acid-related gastrointestinal diseases. Int J Clin Pract 2005;59:709–15PubMed CrossRef
29.Blume H, Donath F, Warnke A, Schug BS. Pharmacokinetic drug interaction profiles of proton pump inhibitors. Drug Saf 2006;29:769–84PubMed CrossRef
30.Williams C, McColl KE. Review article: proton pump inhibitors and bacterial overgrowth. Aliment Pharmacol Ther 2006;23:3–10PubMed CrossRef
31.Del Piano M, Pagliarulo M, Tari R, Carmagnola S, Balzarini M, Lorenzini P, et al. Correlation between chronic treatment with proton pump inhibitors and bacterial overgrowth in the stomach: any possible beneficial role for selected lactobacilli? J Clin Gastroenterol 2014;48 Suppl 1:S40–6PubMed CrossRef
32.Laheij RJ, Sturkenboom MC, Hassing RJ, Dieleman J, Stricker BH, Jansen JB. Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs. JAMA 2004;292:1955–60PubMed CrossRef
33.Buendgens L, Bruensing J, Matthes M, Duckers H, Luedde T, Trautwein C, et al. Administration of proton pump inhibitors in critically ill medical patients is associated with increased risk of developing Clostridium difficile-associated diarrhea. J Crit Care 2014;29:696 e11–5PubMed CrossRef
34.Cunningham R, Dale B, Undy B, Gaunt N. Proton pump inhibitors as a risk factor for Clostridium difficile diarrhoea. J Hosp Infect 2003;54:243–5PubMed CrossRef
35.Monk BC, Mason AB, Abramochkin G, Haber JE, Seto-Young D, Perlin DS. The yeast plasma membrane proton pumping ATPase is a viable antifungal target. I. Effects of the cysteine-modifying reagent omeprazole. Biochim Biophys Acta 1995;1239:81–90PubMed CrossRef
36.Nakao M, Malfertheiner P. Growth inhibitory and bactericidal activities of lansoprazole compared with those of omeprazole and pantoprazole against Helicobacter pylori. Helicobacter 1998;3:21–7PubMed CrossRef
37.Gonzalez P, Soriano V, Lopez P, Niveiro E. Anaphylaxis to proton pump inhibitors. Allergol Immunopathol (Madr) 2002;30:342–3CrossRef
38.Kollmeier AP, Eddleston J, Zuraw BL, Christiansen SC. Recurrent anaphylaxis linked to pantoprazole. J Allergy Clin Immunol 2004;114:975–7PubMed CrossRef
39.Etherington DJ, Taylor WH. The pepsins from human gastric mucosal extracts. Biochem J 1970;118:587–94PubMed PubMedCentral CrossRef
40.Khan AR, James MN. Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes. Protein Sci 1998;7:815–36PubMed PubMedCentral CrossRef
41.Untersmayr E, Jensen-Jarolim E. The role of protein digestibility and antacids on food allergy outcomes. J Allergy Clin Immunol 2008;121:1301–8; quiz 9–10PubMed PubMedCentral CrossRef
42.Chey WY, Chang TM. Neural control of the release and action of secretin. J Physiol Pharmacol 2003; 54 Suppl 4:105–12PubMed
43.Pali-Schöll I, Jensen-Jarolim E. Anti-acid medication as a risk factor for food allergy. Allergy 2011;66:469–77PubMed CrossRef
44.Mullin JM, Valenzano MC, Whitby M, Lurie D, Schmidt JD, Jain V, et al. Esomeprazole induces upper gastrointestinal tract transmucosal permeability increase. Aliment Pharmacol Ther 2008;28:1317–25PubMed CrossRef
45.van Rhijn BD, Weijenborg PW, Verheij J, van den Bergh Weerman MA, Verseijden C, van den Wijngaard RM, et al. Proton pump inhibitors partially restore mucosal integrity in patients with proton pump inhibitor-responsive esophageal eosinophilia but not eosinophilic esophagitis. Clin Gastroenterol Hepatol 2014;12:1815–23 e2PubMed CrossRef
46.Ligumsky M, Karmeli F, Rachmilewitz D. Sucralfate protection against gastrointestinal damage: possible role of prostanoids. Isr J Med Sci 1986;22:801–6PubMed
47.Wallace JL, Morris GP, Beck PL, Williamson TE, Gingras GR. Effects of sucralfate on gastric prostaglandin and leukotriene synthesis: relationship to protective actions. Can J Physiol Pharmacol 1988;66:666–70PubMed CrossRef
48.Morris GP, Keenan CM, MacNaughton WK, Wallace JL, Williamson TE. Protection of rat gastric mucosa by sucralfate. Effects of luminal stasis and of inhibition of prostaglandins synthesis. Am J Med 1989;86:10–6PubMed CrossRef
49.Jensen-Jarolim E. Aluminium in Allergies and Allergen immunotherapy. World Allergy Organ J 2015;8:7PubMed PubMedCentral CrossRef
50.Brunner R, Wallmann J, Szalai K, Karagiannis P, Kopp T, Scheiner O, et al. The impact of aluminium in acid-suppressing drugs on the immune response of BALB/c mice. Clin Exp Allergy 2007;37:1566–73PubMed CrossRef
51.O’Mahony L, Akdis M, Akdis CA. Regulation of the immune response and inflammation by histamine and histamine receptors. J Allergy Clin Immunol 2011;128:1153–62PubMed CrossRef
52.Smolinska S, Jutel M, Crameri R, O’Mahony L. Histamine and gut mucosal immune regulation. Allergy 2014;69:273–81PubMed CrossRef
53.Frei R, Ferstl R, Konieczna P, Ziegler M, Simon T, Rugeles TM, et al. Histamine receptor 2 modifies dendritic cell responses to microbial ligands. J Allergy Clin Immunol 2013;132:194–204PubMed CrossRef
54.Biswas S, Benedict SH, Lynch SG, LeVine SM. Potential immunological consequences of pharmacological suppression of gastric acid production in patients with multiple sclerosis. BMC Med 2012;10:57PubMed PubMedCentral CrossRef
55.Juillerat P, Schneeweiss S, Cook EF, Ananthakrishnan AN, Mogun H, Korzenik JR. Drugs that inhibit gastric acid secretion may alter the course of inflammatory bowel disease. Aliment Pharmacol Ther 2012;36:239–47PubMed CrossRef
56.Biswas K, Bandyopadhyay U, Chattopadhyay I, Varadaraj A, Ali E, Banerjee RK. A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. J Biol Chem 2003;278:10993–1001PubMed CrossRef
57.Lapenna D, de Gioia S, Ciofani G, Festi D, Cuccurullo F. Antioxidant properties of omeprazole. FEBS Lett 1996;382:189–92PubMed CrossRef
58.Kedika RR, Souza RF, Spechler SJ. Potential anti-inflammatory effects of proton pump inhibitors: a review and discussion of the clinical implications. Dig Dis Sci 2009;54:2312–7PubMed PubMedCentral CrossRef
59.Suzuki M, Nakamura M, Mori M, Miura S, Tsuchiya M, Ishii H. Lansoprazole inhibits oxygen-derived free radical production from neutrophils activated by Helicobacter pylori. J Clin Gastroenterol 1995; 20 Suppl 2:S93–6PubMed CrossRef
60.Liu W, Baker SS, Trinidad J, Burlingame AL, Baker RD, Forte JG, et al. Inhibition of lysosomal enzyme activities by proton pump inhibitors. J Gastroenterol 2013;48:1343–52PubMed CrossRef
61.Han YM, Hahm KB, Park JM, Hong SP, Kim EH. Paradoxically augmented anti-tumorigenic action of proton pump inhibitor and GastrininAPCMin/+ intestinal polyposis model. Neoplasia 2014;16:73–83PubMed PubMedCentral CrossRef
62.De Milito A, Marino ML, Fais S. A rationale for the use of proton pump inhibitors as antineoplastic agents. Curr Pharm Des 2012;18:1395–406PubMed CrossRef
63.Larussa T, Suraci E, Leone I, Nazionale I, Abenavoli L, Galasso O, et al. Short-term therapy with celecoxib and lansoprazole modulates Th1/ Th2 immune response in human gastric mucosa. Helicobacter 2010;15:449–59PubMed CrossRef
64.Sasaki T, Yamaya M, Yasuda H, Inoue D, Yamada M, Kubo H, et al. The proton pump inhibitor lansoprazole inhibits rhinovirus infection in cultured human tracheal epithelial cells. Eur J Pharmacol 2005;509:201–10PubMed CrossRef
65.Cortes JR, Rivas MD, Molina-Infante J, Gonzalez-Nunez MA, Perez GM, Masa JF, et al. Omeprazole inhibits IL-4 and IL-13 signaling signal transducer and activator of transcription 6 activation and reduces lung inflammation in murine asthma. J Allergy Clin Immunol 2009; 124:607–10,10 e1PubMed CrossRef
66.Molina-Infante J, Rivas MD, Hernandez-Alonso M, Vinagre-Rodriguez G, Mateos-Rodriguez JM, Duenas-Sadornil C, et al. Proton pump inhibitor-responsive oesophageal eosinophilia correlates with downregulation of eotaxin-3 and Th2 cytokines overexpression. Aliment Pharmacol Ther 2014;40:955–65PubMed CrossRef
67.Untersmayr E, Focke M, Kinaciyan T, Poulsen LK, Boltz-Nitulescu G, Scheiner O, et al. Anaphylaxis to Russian Beluga caviar. J Allergy Clin Immunol 2002;109:1034–5PubMed CrossRef
68.Schöll I, Untersmayr E, Bakos N, Roth-Walter F, Gleiss A, Boltz-Nitulescu G, et al. Antiulcer drugs promote oral sensitization and hypersensitivity to hazelnut allergens in BALB/c mice and humans. Am J Clin Nutr 2005;81:154–60PubMed
69.Untersmayr E, Schöll I, Swoboda I, Beil WJ, Förster-Waldl E, Walter F, et al. Antacid medication inhibits digestion of dietary proteins and causes food allergy: a fish allergy model in BALB/c mice. J Allergy Clin Immunol 2003;112:616–23PubMed CrossRef
70.Arae K, Oboki K, Ohno T, Hirata M, Nakae S, Taguchi H, et al. Cimetidine enhances antigen-specific IgE and Th2 cytokine production. Allergol Int 2011;60:339–44PubMed CrossRef
71.Pali-Schöll I, Herzog R, Wallmann J, Szalai K, Brunner R, Lukschal A, et al. Antacids and dietary supplements with an influence on the gastric pH increase the risk for food sensitization. Clin Exp Allergy 2010;40:1091–8PubMed PubMedCentral CrossRef
72.Untersmayr E, Bakos N, Schöll I, Kundi M, Roth-Walter F, Szalai K, et al. Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients. FASEB J 2005;19:656–8PubMed
73.Schöll I, Ackermann U, Ozdemir C, Blumer N, Dicke T, Sel S, et al. Anti-ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2-bias in their offspring. FASEB J 2007;21:1264–PubMed PubMedCentral CrossRef
74.Dehlink E, Yen E, Leichtner AM, Hait EJ, Fiebiger E. First evidence of a possible association between gastric acid suppression during pregnancy and childhood asthma: a population-based register study. Clin Exp Allergy 2009;39:246–53PubMed CrossRef
75.DeMuth K, Stecenko A, Sullivan K, Fitzpatrick A. Relationship between treatment with antacid medication and the prevalence of food allergy in children. Allergy Asthma Proc 2013;34:227–32PubMed CrossRef
76.Trikha A, Baillargeon JG, Kuo YF, Tan A, Pierson K, Sharma G, et al. Development of food allergies in patients with gastroesophageal reflux disease treated with gastric acid suppressive medications. Pediatr Allergy Immunol 2013;24:582–8PubMed PubMedCentral CrossRef
77.Untersmayr E, Diesner SC, Brämswig KH, Knittelfelder R, Bakos N, Gundacker C, et al. Characterization of intrinsic and extrinsic risk factors for celery allergy in immunosenescence. Mech Ageing Dev 2008;129:120–8PubMed CrossRef
78.Bakos N, Schöll I, Szalai K, Kundi M, Untersmayr E, Jensen-Jarolim E. Risk assessment in elderly for sensitization to food and respiratory allergens. Immunol Lett 2006;107:15–21PubMed CrossRef
79.Untersmayr E, Poulsen LK, Platzer MH, Pedersen MH, Boltz-Nitulescu G, Skov PS, et al. The effects of gastric digestion on codfish allergenicity. J Allergy Clin Immunol 2005;115:377–82PubMed CrossRef
80.Untersmayr E, Vestergaard H, Malling HJ, Jensen LB, Platzer MH, Boltz-Nitulescu G, et al. Incomplete digestion of codfish represents a risk factor for anaphylaxis in patients with allergy. J Allergy Clin Immunol 2007;119:711–7PubMed PubMedCentral CrossRef
81.Riemer AB, Gruber S, Pali-Schöll I, Kinaciyan T, Untersmayr E, Jensen-Jarolim E. Suppression of gastric acid increases the risk of developing immunoglobulin E-mediated drug hypersensitivity: human diclofenac sensitization and a murine sensitization model. Clin Exp Allergy 2010;40:486–93PubMed PubMedCentral CrossRef
82.Ramirez E, Cabanas R, Laserna LS, Fiandor A, Tong H, Prior N, et al. Proton pump inhibitors are associated with hypersensitivity reactions to drugs in hospitalized patients: a nested case-control in a retrospective cohort study. Clin Exp Allergy 2013;43:344–52PubMed CrossRef
83.Molina-Infante J, Hernandez-Alonso M, Vinagre-Rodriguez G, Martin-Noguerol E. Proton pump inhibitors therapy for esophageal eosinophilia: simply following consensus guidelines. J Gastroenterol 2011;46:712–3; author reply 4–5PubMed CrossRef
84.Asher Wolf W, Dellon ES. Eosinophilic esophagitis and proton pump inhibitors: controversies and implications for clinical practice. Gastroenterol Hepatol 2014;10:427–32
85.Zhang X, Cheng E, Huo X, Yu C, Zhang Q, Pham TH, et al. Omeprazole blocks STAT6 binding to the eotaxin-3 promoter in eosinophilic esophagitis cells. PLoS One 2012;7:e50037PubMed PubMedCentral CrossRef
86.Shakeri-Leidenmühler S, Lukschal A, Schultz C, Bohdjalian A, Langer F, Birsan T, et al. Surgical elimination of the gastric digestion by Roux-en-Y gastric bypass impacts on food sensitization - a pilot study. Obes Surg. 2015 Apr 25. Epub ahead of print
87.Astwood JD, Leach JN, Fuchs RL. Stability of food allergens to digestion in vitro. Nat Biotechnol 1996;14:1269–73PubMed CrossRef
88.Aalberse RC. Food allergens. Environ Toxicol Pharmacol 1997; 4:55–60PubMed CrossRef
89.Fu TJ. Digestion stability as a criterion for protein allergenicity assessment. Ann N Y Acad Sci 2002;964:99–110PubMed CrossRef
90.Muckerheide A, Pesce AJ, Michael JG. Immunosuppressive properties of a peptic fragment of BSA. J Immunol 1977;119:1340–5PubMed
91.Zhang Z, Apple RJ, Pesce A, Michael JG. Peptic fragments of bovine serum albumin bind antigen-specific T suppressor cells from orally tolerized mice. Cell Immunol 1987;104:426–33PubMed CrossRef
92.Eiwegger T, Rigby N, Mondoulet L, Bernard H, Krauth MT, Boehm A, et al. Gastro-duodenal digestion products of the major peanut allergen Ara h 1 retain an allergenic potential. Clin Exp Allergy 2006;36:1281–8PubMed CrossRef
93.Hong SJ, Michael JG, Fehringer A, Leung DY. Pepsin-digested peanut contains T-cell epitopes but no IgE epitopes. J Allergy Clin Immunol 1999;104:473–8PubMed CrossRef
94.Akkerdaas JH, Wensing M, Asero R, Fernandez Rivas M, Knulst AC, Bolhaar S, et al. IgE binding to pepsin-digested food extracts. Int Arch Allergy Immunol 2005;138:203–8PubMed CrossRef
95.Kulis M, Macqueen I, Li Y, Guo R, Zhong XP, Burks AW. Pepsinized cashew proteins are hypoallergenic and immunogenic and provide effective immunotherapy in mice with cashew allergy. J Allergy Clin Immunol 2012;130:716–23PubMed CrossRef
96.Meulenbroek LA, van Esch BC, Hofman GA, den Hartog Jager CF, Nauta AJ, Willemsen LE, et al. Oral treatment with beta-lactoglobulin peptides prevents clinical symptoms in a mouse model for cow’s milk allergy. Pediatr Allergy Immunol 2013;24:656–64PubMed CrossRef
97.Price D, Ackland L, Suphioglu C. Nuts ‚n’ guts: transport of food allergens across the intestinal epithelium. Asia Pac Allergy 2013;3:257–65PubMed PubMedCentral CrossRef
98.Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 2009;9:799–809PubMed CrossRef
99.De Lazzari F, Mancin O, Plebani M, Venturi C, Battaglia G, Vianello F, et al. High IgE serum levels and „peptic“ ulcers: clinical and functional approach. Ital J Gastroenterol 1994;26:7–11PubMed
100.Matysiak-Budnik T, Coffin B, Lavergne-Slove A, Sabate JM, Megraud F, Heyman M. Helicobacter pylori increases the epithelial permeability to a food antigen in human gastric biopsies. Am J Gastroenterol 2004;99:225–32PubMed CrossRef
101.Mullin JM, Valenzano MC, Trembeth S, Allegretti PD, Verrecchio JJ, Schmidt JD, et al. Transepithelial leak in Barrett’s esophagus. Dig Dis Sci 2006;51:2326–36PubMed CrossRef
102.Bajaj JS, Cox IJ, Betrapally NS, Heuman DM, Schubert ML, Ratneswaran M, et al. Systems biology analysis of omeprazole therapy in cirrhosis demonstrates significant shifts in gut microbiota composition and function. Am J Physiol Gastrointest Liver Physiol 2014;307:G951–7PubMed PubMedCentral CrossRef
103.Verdu E, Viani F, Armstrong D, Fraser R, Siegrist HH, Pignatelli B, et al. Effect of omeprazole on intragastric bacterial counts, nitrates, nitrites, and N-nitroso compounds. Gut 1994;35:455–60PubMed PubMedCentral CrossRef
104.Vesper BJ, Jawdi A, Altman KW, Haines GK, 3rd, Tao L, Radosevich JA. The effect of proton pump inhibitors on the human microbiota. Curr Drug Metab 2009;10:84–9PubMed CrossRef
105.Noval Rivas M, Burton OT, Wise P, Zhang YQ, Hobson SA, Garcia Lloret M, et al. A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis. J Allergy Clin Immunol 2013;131:201–12PubMed CrossRef
106.Stefka AT, Feehley T, Tripathi P, Qiu J, McCoy K, Mazmanian SK, et al. Commensal bacteria protect against food allergen sensitization. Proc Natl Acad Sci U S A 2014;111:13145–50PubMed PubMedCentral CrossRef - 作者单位：Eva Untersmayr MD, PhD (1)
1. Department of Pathophysiology and Allergy Research, Medical University of Vienna, Waehringer Guertel 18–20, 1090, Vienna, Austria - 刊物主题：General Practice / Family Medicine;
- 出版者：Urban & Vogel
- ISSN：2195-6405
文摘