Understanding Frailty, Aging, and Inflammation in HIV Infection

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• 作者：Sean X. Leng (1)
  Joseph B. Margolick (2)
  
  1. Division of Geriatric Medicine and Gerontology ; Department of Medicine ; Johns Hopkins University School of Medicine ; John R. Burton Pavilion ; 5505 Hopkins Bayview Circle ; Baltimore ; MD ; 21224 ; USA
  2. Molecular Microbiology and Immunology ; Johns Hopkins Bloomberg School of Public Health ; 615 N. Wolfe St. ; Room E5153 ; Baltimore ; MD ; 21205 ; USA
  
• 关键词：Frailty ; Inflammation ; HIV infection ; IL ; 6 ; T cell immunity ; CMV infection
• 刊名：Current HIV/AIDS Reports
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：12
• 期：1
• 页码：25-32
• 全文大小：257 KB
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• 刊物主题：Medicine/Public Health, general;
• 出版者：Springer US
• ISSN：1548-3576

文摘

Frailty is a clinical syndrome initially characterized in geriatric populations with a hallmark of age-related declines in physiologic reserve and function and increased vulnerability to adverse health outcomes. Recently, frailty has increasingly been recognized as a common and important HIV-associated non-AIDS (HANA) condition. This article provides an overview of our current understanding of frailty and its phenotypic characteristics and evidence that they are related to aging and to chronic inflammation that is associated with aging and also with long-term treated HIV infection. The etiology of this chronic inflammation is unknown but we discuss evidence linking it to persistent infection with cytomegalovirus in both geriatric populations and people living with HIV infection.