Effects of l-methamphetamine treatment on cocaine- and food-maintained behavior in rhesus monkeys

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• 作者：Stephen J. Kohut ; Jack Bergman ; Bruce E. Blough
• 关键词：Cocaine ; Self ; administration ; Drug discrimination ; Dopamine ; Norepinephrine ; Agonist therapy
• 刊名：Psychopharmacology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：233
• 期：6
• 页码：1067-1075
• 全文大小：509 KB
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• 作者单位：Stephen J. Kohut (1)
  Jack Bergman (1)
  Bruce E. Blough (2)
  
  1. Department of Psychiatry, McLean Hospital—Harvard Medical School, 115 Mill Street, Belmont, MA, 02478, USA
  2. Center for Organic and Medicinal Chemistry, Research Triangle Institute, Research Triangle Park, Durham, NC, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072

文摘

Rationale Monoamine releasers with prominent dopaminergic actions, e.g., d-methamphetamine (d-MA), significantly reduce cocaine use and craving in clinical and preclinical laboratory studies. However, D-MA and related drugs also display high abuse potential, which limits their acceptability as agonist replacement medications for the management of Cocaine Use Disorder.