Cocaine-like discriminative stimulus effects of amphetamine, cathinone, methamphetamine, and their 3,4-methylenedioxy analogs in male rhesus monkeys

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• 作者：Douglas A. Smith ; Bruce E. Blough ; Matthew L. Banks
• 关键词：Discrimination ; Amphetamine ; Cathinone ; Methamphetamine ; MDMA ; Rhesus monkey
• 刊名：Psychopharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：234
• 期：1
• 页码：117-127
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Neurosciences; Pharmacology/Toxicology; Psychiatry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-2072
• 卷排序：234

文摘

RationaleSynthetic cathinones have emerged as the newest class of abused monoamine transporter substrates. Structurally, these compounds are all beta-ketone amphetamine (cathinone) analogs. Whether synthetic cathinone analogs produce differential behavioral effects from their amphetamine analog counterparts has not been systematically examined. Preclinical drug discrimination procedures have been useful for determining the structure activity relationships (SARs) of abused drugs; however, direct comparisons between amphetamine and cathinone analogs are lacking and, in particular, in non-human primate models.