Developmental Programming: Priming Disease Susceptibility for Subsequent Generations

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• 作者：L. C. Messer ; J. Boone-Heinonen ; L. Mponwane ; L. Wallack…
• 关键词：Developmental programming ; Health disparities ; Social epidemiology ; Priming ; Air pollutants ; Psychosocial stress ; Diet
• 刊名：Current Epidemiology Reports
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：2
• 期：1
• 页码：37-51
• 全文大小：513KB
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• 作者单位：L. C. Messer (1)
  J. Boone-Heinonen (2)
  L. Mponwane (1)
  L. Wallack (1)
  K. L. Thornburg (3)
  
  1. School of Community Health, College of Urban and Public Affairs, Portland State University, Portland, OR, USA
  2. Department of Public Health and Preventive Medicine, Oregon Health & Science University, Portland, OR, USA
  3. Moore Institute, Oregon Health & Science University, Portland, OR, USA
  
• 刊物类别：Epidemiology;
• 刊物主题：Epidemiology;
• 出版者：Springer International Publishing
• ISSN：2196-2995

文摘

Racial and/or ethnic minorities carry the highest burden of many adverse health outcomes intergenerationally. We propose a paradigm in which developmental programming exacerbates the effects of racial patterning of adverse environmental conditions, thereby contributing to health disparity persistence. Evidence that developmental programming induces a heightened response to adverse exposures (鈥渟econd hits鈥? encountered later in life is considered. We evaluated the evidence for the second hit phenomenon reported in animal and human studies from three domains (air, stress, nutrition). Original research including a gestational exposure and a childhood or adulthood second hit exposure was reviewed. Evidence from animal studies suggest that prenatal exposure to air pollutants is associated with an exaggerated reaction to postnatal air pollution exposure, which results in worse health outcomes. It also indicates offspring exposed to prenatal maternal stress produce an exaggerated response to subsequent stressors, including anxiety and hyper-responsiveness of the hypothalamic鈥損ituitary鈥揳drenal axis. Similarly, prenatal and postnatal Western-style diets induce synergistic effects on weight gain, metabolic dysfunction, and atherosclerotic risk. Cross-domain second hits (e.g., gestational air pollution followed by childhood stressor) were also considered. Suboptimal gestational environments induce exaggerated offspring responses to subsequent environmental and social exposures. These developmental programming effects may result in enhanced sensitivity of ongoing, racially patterned, adverse exposures in race/ethnic minorities, thereby exacerbating health disparities from one generation to the next. Empirical assessment of the hypothesized role of priming processes in the propagation of health disparities is needed. Future social epidemiology research must explicitly consider synergistic relationships among social environmental conditions to which gestating females are exposed and offspring exposures when assessing causes for persistent health disparities. Keywords Developmental programming Health disparities Social epidemiology Priming Air pollutants Psychosocial stress Diet