Heat shock protein 70 gene polymorphisms are associated with paranoid schizophrenia in the Polish population
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- 作者：Malgorzata Kowalczyk (1)
Aleksander Owczarek (2)
Renata Suchanek (1)
Monika Paul-Samojedny (1)
Anna Fila-Danilow (1)
Paulina Borkowska (1)
Krzysztof Kucia (3)
Jan Kowalski (1) - 关键词：Association study ; Paranoid schizophrenia ; HSP70 gene ; Single nucleotide polymorphism ; Haplotype
- 刊名：Cell Stress and Chaperones
- 出版年：2014
- 出版时间：March 2014
- 年：2014
- 卷：19
- 期：2
- 页码：205-215
- 全文大小：269 KB
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60. Ziegler A, Van Steen K, Wellek S (2011) Investigating Hardy–Weinberg equilibrium in case–control or cohort studies or meta-analysis. Breast Cancer Res Treat 128:197-01. doi:10.1007/s10549-010-1295-z g/10.1007/s10549-010-1295-z" target="_blank" title="It opens in new window">CrossRef - 作者单位：Malgorzata Kowalczyk (1)
Aleksander Owczarek (2)
Renata Suchanek (1)
Monika Paul-Samojedny (1)
Anna Fila-Danilow (1)
Paulina Borkowska (1)
Krzysztof Kucia (3)
Jan Kowalski (1)
1. Department of Medical Genetics, Medical University of Silesia, Ostrogorska 30, 41-200, Sosnowiec, Poland
2. Division of Statistics, Department of Instrumental Analysis, Medical University of Silesia, Ostrogorska 30, 41-200, Sosnowiec, Poland
3. Department of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Ziolowa 45, 40-635, Katowice, Poland - ISSN：1466-1268
文摘
HSP70 genes have been considered as promising schizophrenia candidate genes based on their protective role in the central nervous system under stress conditions. In this study, we analyzed the potential implication of HSPA1A +190G/C, HSPA1B +1267A/G, and HSPA1L +2437T/C polymorphisms in the susceptibility to paranoid schizophrenia in a homogenous Caucasian Polish population. In addition, we investigated the association of the polymorphisms with the clinical variables of the disease. Two hundred and three patients with paranoid schizophrenia and 243 healthy controls were enrolled in the study. Polymorphisms of HSPA1A, -1B, and -1L genes were genotyped using the PCR-RFLP technique. Analyses were conducted in entire groups and in subgroups that were stratified according to gender. There were significant differences in the genotype and allele frequencies of HSPA1A polymorphism between the patients and controls. The +190CC genotype and +190C allele were over-represented in the patients and significantly increased the risk for developing schizophrenia (OR--.45 and OR--.61, respectively). Interestingly, such a risk was higher for females with the +190CC genotype than for males with the +190CC genotype (OR--.78 vs. OR--.76). We also identified the CGT haplotype as a risk haplotype for schizophrenia and demonstrated the effects of HSPA1A and HSPA1B genotypes on the psychopathology and age of onset. Our study provided the first evidence that the HSPA1A polymorphism may potentially increase the risk of developing paranoid schizophrenia. Further independent analyses in different populations to evaluate the role of gender are needed to replicate these results.