Major liver resection results in early exacerbation of insulin resistance, and may be a risk factor of developing overt diabetes in the future
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- 作者：Adam Durczynski (1)
Janusz Strzelczyk (1)
Katarzyna Wojciechowska-Durczynska (2)
Anna Borkowska (3)
Piotr Hogendorf (1)
Dariusz Szymanski (1)
Justyna Chalubinska (4)
Leszek Czupryniak (3) - 关键词：Liver tumor ; Hemihepatecomy ; Glucose homoeostasis
- 刊名：Surgery Today
- 出版年：2013
- 出版时间：May 2013
- 年：2013
- 卷：43
- 期：5
- 页码：534-538
- 全文大小：230KB
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24. Schindler R, Mancilla J, Endres S, Ghorbani R, Clark SC, Dinarello CA. Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood. 1990;75(1):40-. - 作者单位：Adam Durczynski (1)
Janusz Strzelczyk (1)
Katarzyna Wojciechowska-Durczynska (2)
Anna Borkowska (3)
Piotr Hogendorf (1)
Dariusz Szymanski (1)
Justyna Chalubinska (4)
Leszek Czupryniak (3)
1. Department of General and Transplant Surgery, Barlicki University Hospital, Medical University of Lodz, Kopcinskiego Street 22, 90-153, Lodz, Poland
2. Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital, Medical University of Lodz, Lodz, Poland
3. Department of Internal Medicine and Diabetology, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
4. Department of Radiation Oncology, Kopernik Memorial Hospital, Medical University of Lodz, Lodz, Poland - ISSN：1436-2813
文摘
Purpose This single center prospective cohort study evaluated the influence of hemihepatectomy on glucose homeostasis. Methods The study included 30 patients undergoing hemihepatectomy. All patients underwent an oral 75?g glucose tolerance test before (baseline), 1?week and 1?month after the surgery. Plasma glucose, insulin and glucagon were measured in the OGTT samples, and the HOMA index was calculated. The fasting levels of interleukin 6 and 1β, tumor necrosis factor and adiponectin were assessed. Results The fasting plasma and 120-min post-challenge mean glucose level increased during the study from 89.6 to 103.5?mg/dl (by 15.5?%) and from 136.4 to 162.2 (by 18.9?%; p?=?0.51), respectively, accompanied by an increase in fasting glucagon (from 3.2 to 5.9?ng/mL; p?=?0.043) and insulin (from 14.6 to 19.3?IU/mL) and by a decrease in plasma insulin at 60?min of OGTT (p?=?0.34). An increase of IL-6 (p?=?0.015) and TNF (from 49.7 to 53?pg/mL), and decrease of plasma APO (7658 to 5152?ng/mL) and exacerbation of insulin resistance (p?=?0.007) were noted. Conclusion Hemihepatectomy resulted in moderate disturbances in glucose homeostasis, in a majority of patients that was likely to be of minor clinical relevance. However, the patients might be at higher risk of developing overt diabetes following long-term survival.