A green protocol for the one-pot multicomponent Petasis boronic Mannich reaction using ball milling

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• 作者：R. Hosseinzadeh ; Z. Lasemi ; M. Oloub…
• 关键词：Ball milling ; Petasis boronic Mannich reaction ; Amines ; Boronic acids ; Salicylaldehyde
• 刊名：Journal of the Iranian Chemical Society
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：14
• 期：2
• 页码：347-355
• 全文大小：
• 刊物主题：Analytical Chemistry; Inorganic Chemistry; Physical Chemistry; Biochemistry, general; Organic Chemistry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1735-2428
• 卷排序：14

文摘

Solvent-free reactions of salicylaldehyde with various boronic acids and amines were accomplished under ball-milling conditions to achieve the corresponding alkyl- and arylaminophenols in good to excellent yields. This simple protocol offers advantages such as high yields, shorter reaction times, simple workup procedure and eco-friendliness.