The social brain network in 22q11.2 deletion syndrome: a diffusion tensor imaging study

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• 作者：Amy K. Olszewski ; Zora Kikinis ; Christie S. Gonzalez…
• 关键词：22q11.2 deletion syndrome ; Social brain network ; Social cognition ; Two ; tensor tractography ; White matter tracts
• 刊名：Behavioral and Brain Functions
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：13
• 期：1
• 全文大小：1336KB
• 刊物主题：Neurosciences; Neurology; Behavioral Therapy; Psychiatry;
• 出版者：BioMed Central
• ISSN：1744-9081
• 卷排序：13

文摘

BackgroundChromosome 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder that is associated with a 25-fold increase in schizophrenia. Both individuals with 22q11.2DS and those with schizophrenia present with social cognitive deficits, which are putatively subserved by a network of brain regions that are involved in the processing of social cognitive information. This study used two-tensor tractography to examine the white matter tracts believed to underlie the social brain network in a group of 57 young adults with 22q11.2DS compared to 30 unaffected controls.