A purine-rich element in foamy virus pol regulates env splicing and gag/pol expression

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• 作者：Rebecca Moschall ; Sarah Denk ; Steffen Erkelenz ; Christian Schenk…
• 关键词：Splice regulation ; Foamy viruses ; Branch point ; Purine ; rich element ; RNA export
• 刊名：Retrovirology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：14
• 期：1
• 全文大小：1666KB
• 刊物主题：Virology; Infectious Diseases; Cancer Research; Vaccine; Antibodies; Protein Structure;
• 出版者：BioMed Central
• ISSN：1742-4690
• 卷排序：14

文摘

BackgroundThe foamy viral genome encodes four central purine-rich elements localized in the integrase-coding region of pol. Previously, we have shown that the first two of these RNA elements (A and B) are required for protease dimerization and activation. The D element functions as internal polypurine tract during reverse transcription. Peters et al., described the third element (C) as essential for gag expression suggesting that it might serve as an RNA export element for the unspliced genomic transcript.