Cardiac MR Elastography: Comparison with left ventricular pressure measurement

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• 作者：Thomas Elgeti (1)
  Michael Laule (2)
  Nikola Kaufels (1)
  J?rg Schnorr (1)
  Bernd Hamm (1)
  Abbas Samani (3) (4)
  Jürgen Braun (5)
  Ingolf Sack (1)
  
• 刊名：Journal of Cardiovascular Magnetic Resonance
• 出版年：2009
• 出版时间：December 2009
• 年：2009
• 卷：11
• 期：1
• 全文大小：1173KB
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• 作者单位：Thomas Elgeti (1)
  Michael Laule (2)
  Nikola Kaufels (1)
  J?rg Schnorr (1)
  Bernd Hamm (1)
  Abbas Samani (3) (4)
  Jürgen Braun (5)
  Ingolf Sack (1)
  
  1. Department of Radiology, Charité - Universit?tsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117, Berlin, Germany
  2. Department of Medicine (Cardiology, Angiology, Pulmonology), Charité - Universit?tsmedizin Berlin, Campus Mitte, Berlin, Germany
  3. Department of Medical Biophysics, University of Western Ontario, Ontario, Canada
  4. Department of Electrical and Computer Engineering, University of Western Ontario, Ontario, Canada
  5. Institute of Medical Informatics, Charité - Universit?tsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
  

文摘

Purpose of study To compare magnetic resonance elastography (MRE) with ventricular pressure changes in an animal model. Methods Three pigs of different cardiac physiology (weight, 25 to 53 kg; heart rate, 61 to 93 bpm; left ventricular [LV] end-diastolic volume, 35 to 70 ml) were subjected to invasive LV pressure measurement by catheter and noninvasive cardiac MRE. Cardiac MRE was performed in a short-axis view of the heart and applying a 48.3-Hz shear-wave stimulus. Relative changes in LV-shear wave amplitudes during the cardiac cycle were analyzed. Correlation coefficients between wave amplitudes and LV pressure as well as between wave amplitudes and LV diameter were determined. Results A relationship between MRE and LV pressure was observed in all three animals (R2 ?0.76). No correlation was observed between MRE and LV diameter (R2 ?0.15). Instead, shear wave amplitudes decreased 102 ± 58 ms earlier than LV diameters at systole and amplitudes increased 175 ± 40 ms before LV dilatation at diastole. Amplitude ratios between diastole and systole ranged from 2.0 to 2.8, corresponding to LV pressure differences of 60 to 73 mmHg. Conclusion Externally induced shear waves provide information reflecting intraventricular pressure changes which, if substantiated in further experiments, has potential to make cardiac MRE a unique noninvasive imaging modality for measuring pressure-volume function of the heart.