The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells

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• 作者：Zhiju Zhao ; Shu Li ; Erwei Song ; Suling Liu
• 关键词：breast cancer stem cells ; microRNA ; lncRNA ; histone ; modifier ; Polycomb group proteins
• 刊名：Protein & Cell
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：7
• 期：2
• 页码：89-99
• 全文大小：517 KB
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• 作者单位：Zhiju Zhao (1)
  Shu Li (2)
  Erwei Song (3)
  Suling Liu (1)
  
  1. Innovation Center for Cell Signalling and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science & Technology of China, Hefei, 230027, China
  2. Department of Pathophysiology, Wannan Medical College, Wuhu, 241002, China
  3. Department of Breast Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China
  
• 刊物主题：Biochemistry, general; Protein Science; Cell Biology; Stem Cells; Human Genetics; Developmental Biology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1674-8018

文摘

Cancer stem cells (CSCs), a subpopulation of cancer cells with ability of initiating tumorigenesis, exist in many kinds of tumors including breast cancer. Cancer stem cells contribute to treatment resistance and relapse. Conventional treatments only kill differentiated cancer cells, but spare CSCs. Combining conventional treatments with therapeutic drugs targeting to CSCs will eradicate cancer cells more efficiently. Studying the molecular mechanisms of CSCs regulation is essential for developing new therapeutic strategies. Growing evidences showed CSCs are regulated by non-coding RNA (ncRNA) including microRNAs and long non-coding RNAs (lncRNAs), and histone-modifiers, such as let-7, miR-93, miR-100, HOTAIR, Bmi-1 and EZH2. Herein we review the roles of microRNAs, lncRNAs and histone-modifiers especially Polycomb family proteins in regulating breast cancer stem cells (BCSCs). Keywords breast cancer stem cells microRNA lncRNA histone-modifier Polycomb group proteins