Bone marrow produces sufficient alloreactive natural killer (NK) cells in vivo to cure mice from subcutaneously and intravascularly injected 4T1 breast cancer
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- 作者：Michel van Gelder ; Ariane Vanclée…
- 关键词：4T1 ; Breast cancer ; Immunotherapy ; Alloreactive NK cell ; Hematopoietic stem cell transplantation
- 刊名：Breast Cancer Research and Treatment
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：161
- 期：3
- 页码：421-433
- 全文大小：1221KB
- 刊物类别：Medicine
- 刊物主题：Oncology;
- 出版者：Springer US
- ISSN：1573-7217
- 卷排序：161
文摘
PurposeAdministration of 5 million alloreactive natural killer (NK) cells after low-dose chemo-irradiation cured mice of 4T1 breast cancer, supposedly dose dependent. We now explored the efficacy of bone marrow as alternative in vivo source of NK cells for anti-breast cancer treatment, as methods for in vitro clinical scale NK cell expansion are still in developmental phases.