Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice

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• 作者：Amanda B. Parris ; Qingxia Zhao…
• 关键词：Buformin ; Cancer stem cells ; ErbB ; 2 ; Mammary epithelial cells ; Breast cancer
• 刊名：Journal of Experimental & Clinical Cancer Research
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：36
• 期：1
• 全文大小：4901KB
• 刊物主题：Oncology; Cancer Research; Immunology; Apoptosis;
• 出版者：BioMed Central
• ISSN：1756-9966
• 卷排序：36

文摘

BackgroundMetformin, an FDA-approved drug for the treatment of Type II diabetes, has emerged as a promising anti-cancer agent. Other biguanide analogs, including buformin and phenformin, are suggested to have similar properties. Although buformin was shown to reduce mammary tumor burden in carcinogen models, the anti-cancer effects of buformin on different breast cancer subtypes and the underlying mechanisms remain unclear. Therefore, we aimed to investigate the effects of buformin on erbB-2-overexpressing breast cancer with in vitro and in vivo models.