Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells
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- 作者：Sarah T. Boyle ; Krystyna A. Gieniec ; Carly E. Gregor…
- 关键词：Breast cancer ; Mammary gland ; Chemokine receptor ; CCR7 ; Notch ; Cancer stem cell ; Crosstalk
- 刊名：Molecular Cancer
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：16
- 期：1
- 全文大小：1153KB
- 刊物主题：Cancer Research; Oncology;
- 出版者：BioMed Central
- ISSN：1476-4598
- 卷排序：16
文摘
BackgroundBreast cancer is the major cause of cancer-related mortality in women. It is thought that quiescent stem-like cells within solid tumors are responsible for cancer maintenance, progression and eventual metastasis. We recently reported that the chemokine receptor CCR7, a multi-functional regulator of breast cancer, maintains the stem-like cell population.