Pharmacokinetics of scutellarin and its aglycone conjugated metabolites in rats
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  • 作者:J. M. Huang (1)
    W. Y. Weng (2)
    X. B. Huang (1)
    Y. H. Ji (1)
    E. Chen (1)
  • 关键词:Scutellarin ; scutellarein conjugates ; breviscapine ; pharmacokinetics
  • 刊名:European Journal of Drug Metabolism and Pharmacokinetics
  • 出版年:2005
  • 出版时间:September 2005
  • 年:2005
  • 卷:30
  • 期:3
  • 页码:165-170
  • 全文大小:826KB
  • 参考文献:1. Xu J.M., Huang Z.H. (1991): DengZhan XiXin capsules in the treatment of cerebrovascular disorders in 74 patients. Chin. J. New Drugs Clin. Rem., 10, 260鈥?63.
    2. Xu Q.Y., Li X.X. (1995): Influences of DengZhan XiXin injection on blood viscosity in patients with high blood viscosity. Chin. J. New Drugs Clin. Rem., 14, 233鈥?35.
    3. Zhang J., Li X.S., Zhang W.D. (2002): The advance in studies on chemical component and pharmacology of Erigeron breviscapus. J. Pharm. Pract., 20, 103鈥?07.
    4. Hong H., Liu G.Q. (2004): Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by scutellarin. Life Sci., 74, 2959鈥?973. CrossRef
    5. Lai M.Y., Hsiu S.L., Tsai S.Y., Hou Y.C., Chao P.D.L. (2003): Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats. J. Pharm. Pharmacol., 55, 205鈥?09. CrossRef
    6. Lai M. Y., Hsiu S.L., Chen C.C., Hou Y.C., Chao P.D.L. (2003): Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of scutellariae radix in humans. Biol. Pharm. Bull., 26, 79鈥?3. CrossRef
    7. Hsiu S.L., Huang T.Y., Hou Y.C., Chin D.H., Chao P.D.L. (2002): Comparison of metabolic pharmacokinetics of naringin and naringenin in rabbits. Life Sci., 70, 1481鈥?489. CrossRef
    8. Kabaze F.I., Kokkalou E., Georgarakis M., Niopas I. (2004): Validated high-performance liquid chromatographic method utilizing solid-phase extraction for the simultaneous determination of naringenin and hesperetin in human plasma. J. Chromatogr. B, 801, 363鈥?67. CrossRef
    9. Akao T., Kawabata K., Yanagisawa E., Ishihara K., Mizuhara Y., Wakui Y., Sakashita Y., Kobashi K. (2000): Baicalin, the predominant flavone glucuronide of Scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. J. Pharm. Pharmacol., 52, 1563鈥?568. CrossRef
    10. Muto R., Motozuka T., Nakano M., Tatsumi Y., Sakamoto F., Kosaka N. (1997): The chemical structure of new substance as the metabolite of baicalin and time profiles for the plasma concentration after oral administration of sho-saiko-to in human. Yakugaku Zasshi, 118, 79鈥?7.
    11. Shimoi K., Okada H., Furugori M., Goda T., Takase S., Suzuki M., Hara Y., Yamamoto H., Kinae N. (1998): Intestinal absorption of luteolin and luteolin 7-O-尾-glucoside in rats and humans. FEBS Lett., 438, 220鈥?24. CrossRef
    12. Murota K., Terao J. (2003): Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. Arch. Biochem. Biophys., 417, 12鈥?7. CrossRef
    13. Yang Q., Yang J.Y., Li S.C., Zhang L.M. (2004): The relative bioavailability of breviscapine sustained-release tablets in beagle dogs. West China J. Pharm. Sci., 19, 175鈥?78.
    14. Liu Y.M., Lin A.H., Chen H., Zeng F.D. (2003): Study on pharmacokinetics of scutellarin in rabbits. Acta. Pharm. Sin., 38, 775鈥?78.
    15. Jiang X.H., Li S.H., Lan K., Yang J.Y., Zhou J. (2003): Study on the pharmacokinetics of scutellarin in dogs. Acta. Pharm. Sin., 38, 371鈥?73.
    16. Li S.H., Jiang X.H., Lan K., Yang J.Y., Zhou J. (2003): Pharmacokinetics of scutellarin in dogs. J. Chin. Pharm. Sci., 12, 127鈥?30.
    17. Ge Q.H., Zhou Z., Zhi X.J., Ma L.L., Chen X.H. (2003): Pharmacokinetics and absolute bioavailability of breviscapine in beagle dogs. Chin. J. Pharm., 34, 618鈥?20.
    18. Li S.H., Jiang X.H., Yang Q., Jin C.H. (2003): Pharmacokinetics of scutellarin in rabbits. J. Biomed. Eng., 20, 692鈥?94.
    19. Zhang J.L., Che Q.M., Li S.Z., Zhou T.H. (2003): Study on metabolism of scutellarin in rats by HPLC-MS and HPLC-NMR. J. Asian. Nat. Prod. Res., 5, 249鈥?56. CrossRef
    20. Wang H., Chen J.M., Zhang Q.M. (2000): A study on the absorption kinetics of baicalin in rats鈥?stomachs and small intestines in vitro. J. Shenyang Pharm. Univ., 17, 5鈥?.
    21. Ding J.S., Zhang J.S. (2003): Absorption of breviscapine in small intestine of rat. J. Chin. Pharm. Univ., 34, 65鈥?9.
    22. Murota K., Shimizu S., Chujo H., Moon J.H., Terao J. (2000): Efficiency of absorption and metabolic conversion of quercetin and its glucosides in human intestinal cell line Caco-2. Arch. Biochem. Biophys., 384, 391鈥?97. CrossRef
    23. Nemeth K., Plumb G.W., Benin J.G., Juge N., Jacob R., Nairn H.Y., Williamson G., Swallow D.M., Kroon P.A. (2003): Deglycosylation by small intestinal epithelial cell 尾-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur. J. Nutr., 42, 29鈥?2. CrossRef
  • 作者单位:J. M. Huang (1)
    W. Y. Weng (2)
    X. B. Huang (1)
    Y. H. Ji (1)
    E. Chen (1)

    1. Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, China
    2. Department of Pharmaceutics, School of Pharmacy, Fudan University, 138 Yixueyuan Road, 200032, Shanghai, People鈥檚 Republic of China
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