MTHFR 677C>T effects on anterior cingulate structure and function during response monitoring in schizophrenia: a preliminary study
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- 作者：Joshua L. Roffman (1) (4)
David G. Brohawn (1)
Jesse S. Friedman (1)
Kara A. Dyckman (1)
Katharine N. Thakkar (1)
Yigal Agam (1)
Mark G. Vangel (2) (3)
Donald C. Goff (1)
Dara S. Manoach (1) (3) - 关键词：Schizophrenia ; Functional MRI ; Genetics ; Executive function ; Anterior cingulate cortex ; Diffusion tensor imaging
- 刊名：Brain Imaging and Behavior
- 出版年：2011
- 出版时间：March 2011
- 年：2011
- 卷：5
- 期：1
- 页码：65-75
- 全文大小：461KB
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David G. Brohawn (1)
Jesse S. Friedman (1)
Kara A. Dyckman (1)
Katharine N. Thakkar (1)
Yigal Agam (1)
Mark G. Vangel (2) (3)
Donald C. Goff (1)
Dara S. Manoach (1) (3)
1. Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA
4. Massachusetts General Hospital, 149 13th St, Room 2606, Charlestown, MA, 02129, USA
2. Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA
3. Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, 02129, USA
文摘
Patients with schizophrenia exhibit deficient response monitoring as indexed by blunted activation of the dorsal anterior cingulate cortex (dACC) and functionally related regions during error commission. This pattern may reflect heritable alterations of dACC function. We examined whether the hypofunctional 677C>T variant in MTHFR, a candidate schizophrenia risk gene, contributed to our previous findings of blunted error-related dACC activation and reduced microstructural integrity of dACC white matter. Eighteen medicated outpatients with schizophrenia underwent diffusion tensor imaging and performed an antisaccade paradigm during functional magnetic resonance imaging (fMRI). T allele carriers exhibited significantly less error-related activation than C/C patients in bilateral dACC and substantia nigra, regions that are thought to mediate dopamine-dependent error-based reinforcement learning. T carrier patients also showed significantly lower fractional anisotropy in bilateral dACC. These findings suggest that the MTHFR 677T allele blunts response monitoring in schizophrenia, presumably via effects on dopamine signaling and dACC white matter microstructural integrity.