Airflow, transport and regional deposition of aerosol particles during chronic bronchitis of human central airways

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• 作者：Fouad Farkhadnia ; Tahereh B. Gorji…
• 关键词：Central respiratory airways ; Chronic bronchitis ; CFPD ; Micro ; particle ; Unsteady particle tracking
• 刊名：Australasian Physical & Engineering Sciences in Medicine
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：39
• 期：1
• 页码：43-58
• 全文大小：6,997 KB
• 参考文献：1.Sul B et al (2014) A computational study of the respiratory airflow characteristics in normal and obstructed human airways. Comput Biol Med 52:130–143CrossRef PubMed
  2.Schiller-Scotland CF et al (1996) Deposition of inspired aerosol particles within the respiratory tract of patients with obstructive lung disease. Toxicol Lett 88(1):255–261CrossRef PubMed
  3.Kim CS, Kang TC (1997) Comparative measurement of lung deposition of inhaled fine particles in normal subjects and patients with obstructive airway disease. Am J Respir Crit Care Med 155(3):899–905CrossRef PubMed
  4.Chalupa D et al (2004) Ultrafine particle deposition in subjects with asthma. Environ Health Perspect 112:879–882CrossRef PubMed PubMedCentral
  5.Martonen T et al (2003) In silico modeling of asthma. Adv Drug Deliv Rev 55(7):829–849CrossRef PubMed
  6.Segal R et al (2002) Computer simulations of particle deposition in the lungs of chronic obstructive pulmonary disease patients. Inhalation Toxicol 14(7):705–720CrossRef
  7.Padrid PA et al (1990) Canine chronic bronchitis. A pathophysiologic evaluation of 18 cases. J Vet Intern Med 4(3):172–180CrossRef PubMed
  8.Rozanski E (2014) Canine chronic bronchitis. Veterinary clinics of North America: small animal practice. J Vet Intern Med 44(1):107–116
  9.Comer J, Kleinstreuer C, Zhang Z (2001) Flow structures and particle deposition patterns in double-bifurcation airway models. Part 1. Air flow fields. J Fluid Mech 435:25–54
  10.Comer J, Kleinstreuer C, Kim C (2001) Flow structures and particle deposition patterns in double-bifurcation airway models. Part 2. Aerosol transport and deposition. J Fluid Mech 435:55–80
  11.Zhang Z, Kleinstreuer C (2002) Transient airflow structures and particle transport in a sequentially branching lung airway model (1994-present). Phys Fluids 14(2):862–880CrossRef
  12.Zhang Z, Kleinstreuer C, Kim CS (2002) Aerosol deposition efficiencies and upstream release positions for different inhalation modes in an upper bronchial airway model. Aerosol Sci Technol 36(7):828–844CrossRef
  13.Zhang Z, Kleinstreuer C, Kim C (2002) Cyclic micron-size particle inhalation and deposition in a triple bifurcation lung airway model. J Aerosol Sci 33(2):257–281CrossRef
  14.Zhang Z, Kleinstreuer C, Kim C (2002) Gas–solid two-phase flow in a triple bifurcation lung airway model. Int J Multiph Flow 28(6):1021–1046CrossRef
  15.Zhang Z, Kleinstreuer C (2003) Species heat and mass transfer in a human upper airway model. Int J Heat Mass Transf 46(25):4755–4768CrossRef
  16.Zhang Z et al (2005) Comparison of micro- and nano-size particle depositions in a human upper airway model. J Aerosol Sci 36:211–233CrossRef
  17.Farkas Á, Balásházy I (2008) Quantification of particle deposition in asymmetrical tracheobronchial model geometry. Comput Biol Med 38(4):508–518CrossRef PubMed
  18.Lai T et al (2013) Numerical analysis of particle deposition in asymmetrical human upper airways under different inhalation cycles. J Mech Med Biol 13(04):1350068CrossRef
  19.Segal R et al (2000) Mathematical model of airflow in the lungs of children I: effects of tumor sizes and locations. Comput Math Methods Med 2(3):199–213
  20.Musante C, Martonen T (2001) Computational fluid dynamics in human lungs II. Effects of airway disease. WIT Press, Southampton, pp 147–164
  21.Zhang Z et al (2002) Aerosol transport and deposition in a triple bifurcation bronchial airway model with local tumors. Inhalation Toxicol 14(11):1111–1133CrossRef
  22.Kleinstreuer C, Zhang Z (2003) Targeted drug aeroso deposition analysis for a four-generation lung airway model with hemispherical tumors. J Biomech Eng 125(2):197–206CrossRef PubMed
  23.Longest PW, Vinchurkar S, Martonen T (2006) Transport and deposition of respiratory aerosols in models of childhood asthma. J Aerosol Sci 37(10):1234–1257CrossRef
  24.Yang X, Liu Y, Luo H (2006) Respiratory flow in obstructed airways. J Biomech 39(15):2743–2751CrossRef PubMed
  25.Luo HY, Liu Y, Yang XL (2007) Particle deposition in obstructed airways. J Biomech 40(14):3096–3104CrossRef PubMed
  26.Farkas A, Balásházy I (2007) Simulation of the effect of local obstructions and blockage on airflow and aerosol deposition in central human airways. J Aerosol Sci 38(8):865–884CrossRef
  27.Weibel E (1963) Morphometry of the human lung, Academic Press. , Springer, New York
  28.Oho K, Amemiya R (1980) Practical fiberoptic bronchoscopy. Igaku-Shoin Ltd., Tokyo
  29.Katz I, Davis B, Martonen T (1999) A numerical study of particle motion within the human larynx and trachea. J Aerosol Sci 30(2):173–183CrossRef
  30.Tian G et al (2011) Characterization of respiratory drug delivery with enhanced condensational growth using an individual path model of the entire tracheobronchial airways. Ann Biomed Eng 39(3):1136–1153CrossRef PubMed PubMedCentral
  31.Longest PW et al (2012) Comparing MDI and DPI aerosol deposition using in vitro experiments and a new stochastic individual path (SIP) model of the conducting airways. Pharm Res 29(6):1670–1688CrossRef PubMed
  32.Morsi S, Alexander A (1972) An investigation of particle trajectories in two-phase flow systems. J Fluid Mech 55(02):193–208CrossRef
  33.Zhao Y, Lieber BB (1994) Steady expiratory flow in a model symmetric bifurcation. J Biomech Eng 116(3):318–323CrossRef PubMed
  34.Kim CS, Fisher DM (1999) Deposition characteristics of aerosol particles in sequentially bifurcating airway models. Aerosol Sci Technol 31(2–3):198–220CrossRef
  
• 作者单位：Fouad Farkhadnia (1)
  Tahereh B. Gorji (2)
  Mofid Gorji-Bandpy (2)
  
  1. Mechanical Engineering Group, Mazandaran Institute of Technology, Babol, Iran
  2. Department of Mechanical Engineering, Noshirvani Babol University of Technology, Babol, Iran
  
• 刊物主题：Biomedicine general; Biophysics and Biological Physics; Medical and Radiation Physics; Biomedical Engineering;
• 出版者：Springer Netherlands
• ISSN：1879-5447

文摘

In the present study, the effects of airway blockage in chronic bronchitis disease on the flow patterns and transport/deposition of micro-particles in a human symmetric triple bifurcation lung airway model, i.e., Weibel’s generations G3–G6 was investigated. A computational fluid and particle dynamics model was implemented, validated and applied in order to evaluate the airflow and particle transport/deposition in central airways. Three breathing patterns, i.e., resting, light activity and moderate exercise, were considered. Using Lagrangian approach for particle tracking and random particle injection, an unsteady particle tracking method was performed to simulate the transport and deposition of micron-sized aerosol particles in human central airways. Assuming laminar, quasi-steady, three-dimensional air flow and spherical non-interacting particles in sequentially bifurcating rigid airways, airflow patterns and particle transport/deposition in healthy and chronic bronchitis (CB) affected airways were evaluated and compared. Comparison of deposition efficiency (DE) of aerosols in healthy and occluded airways showed that at the same flow rates DE values are typically larger in occluded airways. While in healthy airways, particles deposit mainly around the carinal ridges and flow dividers—due to direct inertial impaction, in CB affected airways they deposit mainly on the tubular surfaces of blocked airways because of gravitational sedimentation.