Re-surgery and chest wall re-irradiation for recurrent breast cancer - a second curative approach

详细信息    查看全文

• 作者：Arndt-Christian Müller (1)
  Franziska Eckert (1)
  Vanessa Heinrich (1)
  Michael Bamberg (1)
  Sara Brucker (2)
  Thomas Hehr (3)
  
• 刊名：BMC Cancer
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：11
• 期：1
• 全文大小：1264KB
• 参考文献：1. Chen SL, Martinez SR: The survival impact of the choice of surgical procedure after ipsilateral breast cancer recurrence. / Am J Surg 2008,196(4):495-99. CrossRef
  2. Clemons M, Hamilton T, Mansi J, Lockwood G, Goss P: Management of recurrent locoregional breast cancer: oncologist survey. / Breast 2003,12(5):328-37. CrossRef
  3. Bethke KP: Breast conservation: predictors and treatment of local recurrence. / Semin Surg Oncol 1996,12(5):332-38. CrossRef
  4. Lindford AJ, Meretoja TJ, von Smitten KA, Jahkola TA: Skin-sparing mastectomy and immediate breast reconstruction in the management of locally recurrent breast cancer. / Ann Surg Oncol 17(6):1669-674.
  5. Wahl AO, Rademaker A, Kiel KD, Jones EL, Marks LB, Croog V, McCormick BM, Hirsch A, Karkar A, Motwani SB, Tereffe W, Yu TK, Sher D, Silverstein J, Kachnic LA, Kesslering C, Freedman GM, Small W Jr: Multi-institutional review of repeat irradiation of chest wall and breast for recurrent breast cancer. / Int J Radiat Oncol Biol Phys 2008,70(2):477-84. CrossRef
  6. Dahlstrom KK, Andersson AP, Andersen M, Krag C: Wide local excision of recurrent breast cancer in the thoracic wall. / Cancer 1993,72(3):774-77. CrossRef
  7. Schwaibold F, Fowble BL, Solin LJ, Schultz DJ, Goodman RL: The results of radiation therapy for isolated local regional recurrence after mastectomy. / Int J Radiat Oncol Biol Phys 1991,21(2):299-10. CrossRef
  8. Vernon CC, Hand JW, Field SB, Machin D, Whaley JB, van der Zee J, van Putten WL, van Rhoon GC, van Dijk JD, Gonzalez Gonzalez D, Liu FF, Goodman P, Sherar M: Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group. / Int J Radiat Oncol Biol Phys 1996,35(4):731-44. CrossRef
  9. van der Zee J, van der Holt B, Rietveld PJ, Helle PA, Wijnmaalen AJ, van Putten WL, van Rhoon GC: Reirradiation combined with hyperthermia in recurrent breast cancer results in a worthwhile local palliation. / Br J Cancer 1999,79(3-):483-90.
  10. Sack H, Thesen N: / Bestrahlungsplanung. 1st edition. Stuttgart-New York: Georg Thieme Verlag; 1993.
  11. Hehr T, Classen J, Huth M, Durst I, Christ G, Bamberg M, Budach W: Postmastectomy radiotherapy of the chest wall. Comparison of electron-rotation technique and common tangential photon fields. / Strahlenther Onkol 2004,180(10):629-36. CrossRef
  12. Hehr T, Lamprecht U, Glocker S, Classen J, Paulsen F, Budach W, Bamberg M: Thermoradiotherapy for locally recurrent breast cancer with skin involvement. / Int J Hyperthermia 2001,17(4):291-01. CrossRef
  13. Rubin P, Constine LS, Fajardo LF, Phillips TL, Wasserman TH: RTOG Late Effects Working Group. Overview. Late Effects of Normal Tissues (LENT) scoring system. / IntJRadiatOncolBiolPhys 1995,31(5):1041-042.
  14. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. / Jof AmStatAss 1958, 53:457-81.
  15. Freedman GM, Fowble BL: Local recurrence after mastectomy or breast-conserving surgery and radiation. / Oncology (Williston Park) 2000,14(11):1561-581. discussion 1581-562, 1582-564
  16. Alpert TE, Kuerer HM, Arthur DW, Lannin DR, Haffty BG: Ipsilateral breast tumor recurrence after breast conservation therapy: outcomes of salvage mastectomy vs. salvage breast-conserving surgery and prognostic factors for salvage breast preservation. / Int J Radiat Oncol Biol Phys 2005,63(3):845-51. CrossRef
  17. Beck TM, Hart NE, Woodard DA, Smith CE: Local or regionally recurrent carcinoma of the breast: results of therapy in 121 patients. / J Clin Oncol 1983,1(6):400-05.
  18. Stewart FA: Re-treatment after full-course radiotherapy: is it a viable option? / Acta Oncol 1999,38(7):855-62. CrossRef
  19. Cianfrocca M: Overcoming recurrence risk: extended adjuvant endocrine therapy. / Clin Breast Cancer 2008,8(6):493-00. CrossRef
  20. Harbeck N: Never too late: reducing late breast cancer relapse risk. / Curr Med Res Opin 2008,24(12):3295-305. CrossRef
  21. Perez LA, Brady LW: Breast cancer: Locally advanced, inflammatory and recurrent tumors. In . Philadelphia: Lippincott; 2003.
  22. Hehr T, Budach W, Paulsen F, Gromoll C, Christ G, Bamberg M: Evaluation of predictive factors for local tumour control after electron-beam-rotation irradiation of the chest wall in locally advanced breast cancer. / Radiother Oncol 1999,50(3):283-89. CrossRef
  23. Welz S, Hehr T, Lamprecht U, Scheithauer H, Budach W, Bamberg M: Thermoradiotherapy of the chest wall in locally advanced or recurrent breast cancer with marginal resection. / Int J Hyperthermia 2005,21(2):159-67. CrossRef
  24. Jones EL, Oleson JR, Prosnitz LR, Samulski TV, Vujaskovic Z, Yu D, Sanders LL, Dewhirst MW: Randomized trial of hyperthermia and radiation for superficial tumors. / J Clin Oncol 2005,23(13):3079-085. CrossRef
  25. Phromratanapongse P, Steeves RA, Severson SB, Paliwal BR: Hyperthermia and irradiation for locally recurrent previously irradiated breast cancer. / Strahlenther Onkol 1991,167(2):93-7.
  26. Racadot S, Marchal C, Charra-Brunaud C, Verhaeghe JL, Peiffert D, Bey P: [Re-irradiation after salvage mastectomy for local recurrence after a conservative treatment: a retrospective analysis of twenty patients (Nancy: 1988-001)]. / Cancer Radiother 2003,7(6):369-79.
  27. Wagman R, Katz M, Hong L, Mc Cormick B: Re-irradiation of the chest wall for recurrent breast cancer (Abstract). / Int J Radiat Oncol Biol Phys 2002, 54:S237-S238. CrossRef
  28. Gabriele P, Ferrara T, Baiotto B, Garibaldi E, Marini PG, Penduzzu G, Giovannini V, Bardati F, Guiot C: Radio hyperthermia for re-treatment of superficial tumours. / Int J Hyperthermia 2009,25(3):189-98. CrossRef
  29. Bedwinek JM, Lee J, Fineberg B, Ocwieza M: Prognostic indicators in patients with isolated local-regional recurrence of breast cancer. / Cancer 1981,47(9):2232-235. CrossRef
  30. Taghian AG, Jeong JH, Mamounas EP, Parda DS, Deutsch M, Costantino JP, Wolmark N: Low locoregional recurrence rate among node-negative breast cancer patients with tumors 5 cm or larger treated by mastectomy, with or without adjuvant systemic therapy and without radiotherapy: results from five national surgical adjuvant breast and bowel project randomized clinical trials. / J Clin Oncol 2006,24(24):3927-932. CrossRef
  31. McCready DR, Chapman JA, Wall JL, Lickley LA: Characteristics of local recurrence following lumpectomy for breast cancer. / Cancer Invest 1994,12(6):568-73. CrossRef
  32. Harms W, Krempien R, Grehn C, Hensley F, Berns C, Wannenmacher M, Debus J: [Reirradiation of chest wall local recurrences from breast cancer]. / Zentralbl Gynakol 2004,126(1):19-3. CrossRef
  33. Oldenborg S, Van Os RM, Van rij CM, Crezee J, Van de Kamer JB, Rutgers EJ, Geijsen ED, Zum vorde sive vording PJ, Koning CC, Van tienhoven G: Elective re-irradiation and hyperthermia following resection of persistent locoregional recurrent breast cancer: A retrospective study. / Int J Hyperthermia 26(2):136-44.
  34. Dragovic J, Seydel HG, Sandhu T, Kolosvary A, Blough J: Local superficial hyperthermia in combination with low-dose radiation therapy for palliation of locally recurrent breast carcinoma. / J Clin Oncol 1989,7(1):30-5.
  35. van der Zee J, Wijnmaalen AJ, Haveman J, Woudstra E, van der Ploeg SK: Hyperthermia may decrease the development of telangiectasia after radiotherapy. / Int J Hyperthermia 1998,14(1):57-4. CrossRef
  36. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/11/197/prepub
  
• 作者单位：Arndt-Christian Müller (1)
  Franziska Eckert (1)
  Vanessa Heinrich (1)
  Michael Bamberg (1)
  Sara Brucker (2)
  Thomas Hehr (3)
  
  1. Department of Radiooncology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany
  2. Department of Gynecology, Eberhard-Karls-University, Calwerstr. 7, 72076, Tübingen, Germany
  3. Department of Radiooncology, Marienhospital Stuttgart, B?heimstr. 37, 70199, Stuttgart, Germany
  
• ISSN：1471-2407

文摘

Background Repeat radiation is a rarely used treatment strategy that must be performed with caution. The efficacy and toxicity of a second curative radiotherapy series was investigated in cases of recurrent breast cancer. Methods Forty-two patients treated from 1993 to 2003 with resection (n = 30) and postoperative re-irradiation or definitive re-irradiation (n = 12) for recurrent breast cancer were enrolled in the study. Concurrent hyperthermia was performed in 29 patients. The median age was 57 years. The median pre-radiation exposure was 54Gy. Re-irradiation was conventionally fractionated to a median total dose of 60Gy. Results After a median follow-up of 41 months (range 3-92 months) higher graded late toxicity > G3 according to CTC 3.0 and LENT-SOMA was not observed. The estimated 5-year local control rate reached 62%. The estimated 5-year overall survival rate was 59%. Significantly inferior survival was associated with recurrence within two years (40 vs. 71%, p < ([0-9]).01) and presence of macroscopic tumour load (24 vs. 75%, p = 0.03). Conclusions Repeat radiotherapy for recurrent breast cancer with total radiation doses of 60 Gy and the addition of hyperthermia in the majority of patients was feasible, with acceptable late morbidity and improved prognosis, particularly in patients with previous resection of recurrent tumours.