Formation of functional areas in the cerebral cortex is disrupted in a mouse model of autism spectrum disorder

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• 作者：Laura R Fenlon ; Sha Liu ; Ilan Gobius ; Nyoman D Kurniawan…
• 关键词：Autism spectrum disorders (ASD) ; BTBR mice ; Agenesis of the corpus callosum ; Cortical area patterning ; Diffusion imaging
• 刊名：Neural Development
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：10
• 期：1
• 全文大小：2,749 KB
• 刊物主题：Neurosciences; Developmental Biology;
• 出版者：BioMed Central
• ISSN：1749-8104

文摘

Background Autism spectrum disorders (ASD) are a group of poorly understood behavioural disorders, which have increased in prevalence in the past two decades. Animal models offer the opportunity to understand the biological basis of these disorders. Studies comparing different mouse strains have identified the inbred BTBR T + tf/J (BTBR) strain as a mouse model of ASD based on its anti-social and repetitive behaviours. Adult BTBR mice have complete agenesis of the corpus callosum, reduced cortical thickness and changes in early neurogenesis. However, little is known about the development or ultimate organisation of cortical areas devoted to specific sensory and motor functions in these mice that may also contribute to their behavioural phenotype.