Hydrogenation ofmethyl 3a-acetoxy-23-oxo-5b-cholan-24-oatecatalyzed by cinchona alkaloid-modified Pt-alumina catalyst
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- 作者：K¨¢roly Felf?ldi ; Imre Bucsi ; Brigitta Kazi and Mih¨¢ly Bart¨®k
- 关键词：cinchona alkaloids ; enantioselective ; Hydrogenation ; platinum ; alumina ; steroids
- 刊名：Reaction Kinetics and Catalysis Letters
- 出版年：2005
- 出版时间：November 2005
- 年：2005
- 卷：86
- 期：2
- 页码：323-329
- 全文大小：108 KB
文摘
Methyl-3α-acetoxy-23-oxo-5β-cholan-24-oate is hydrogenated with 78 % enantioselection at C23 atom over Pt-alumina catalyst modified with cinchona alkaloids, in liquid phase under mild experimental conditions (293-297 K, hydrogen pressure: 1 bar, concentration of modifiers: 0.1 mmol/L, solvent: THF).