Role of the C3-substituted derivatives of cinchonidine in the enantioselective hydrogenation of ethyl pyruvate on Pt-alumina catalyst in AcOH

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• 作者：Szabolcs Cser¨¦nyi ; Imre Bucsi and K¨¢roly Felf?ldi
• 关键词：hydrogenation ; Enantioselective ; cinchona alkaloids ; Pt/alumina ; substituent effect
• 刊名：Reaction Kinetics and Catalysis Letters
• 出版年：2006
• 出版时间：April 2006
• 年：2006
• 卷：87
• 期：2
• 页码：395-403
• 全文大小：123 KB

文摘

The enantioselective hydrogenation of ethyl pyruvate (EtPy) was studied on Pt-alumina catalysts modified by C3-substituted cinchonidines (NC, A, B, C1, C2in Fig. 1) and for comparison by DHCDand MeO-DHCDin AcOH. The effect of the C3-substituent on the reaction rate and the enantioselectivity were examined. Using the Engelhard 4759 catalyst under mild experimental conditions (room temperature, hydrogen pressure 1 bar) such as DHCDthe (R)-ethyl lactate formed in excess (e.e.max: 79-91 % )</o:p>