Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction

详细信息    查看全文

• 作者：Mari Fihlman ; Tuija Hemmilä ; Nora M. Hagelberg…
• 关键词：Buprenorphine ; Azole antifungals ; Voriconazole ; Posaconazole ; Pharmacokinetics ; Drug ; drug interaction
• 刊名：European Journal of Clinical Pharmacology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：72
• 期：11
• 页码：1363-1371
• 全文大小：380 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1041
• 卷排序：72

文摘

PurposeThis study aimed to determine possible effects of voriconazole and posaconazole on the pharmacokinetics and pharmacological effects of sublingual buprenorphine.