Burkholderia gladioli infection isolated from the blood cultures of newborns in the neonatal intensive care unit

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• 作者：F. Zhou ; H. Ning ; F. Chen ; W. Wu ; A. Chen…
• 刊名：European Journal of Clinical Microbiology & Infectious Diseases
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：34
• 期：8
• 页码：1533-1537
• 全文大小：118 KB
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• 作者单位：F. Zhou (1)
  H. Ning (2)
  F. Chen (1)
  W. Wu (1)
  A. Chen (1)
  J. Zhang (3)
  
  1. Department of Clinical Laboratory, Fujian Medical University Teaching Hospital, First Hospital of Putian, Putian, 351100, China
  2. The Workers and Staff Hospital of HangZhou Steel Group Corp., Hangzhou, 310022, China
  3. The People’s Hospital of Yuxi, Yuxi, Yunnan, 653100, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Medical Microbiology
  Internal Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-4373

文摘

Burkholderia gladioli was described as a plant pathogen, and it is a rare cause of infection in humans that is primarily associated with human pulmonary infections, such as chronic granulomatous disease and cystic fibrosis. The neonatal respiratory system is not fully developed and cannot expel bacterial aerosol properly. A total of 2,676 newborns in the neonatal intensive care unit were retrospectively analysed in Putian City, Fujian Province, China, from 2011 to 2014. All of the blood samples were tested for C-reactive protein (CRP), procalcitonin (PCT) and white blood cell (WBC). B. gladioli infections were determined and analysed using a blood culture system. Antibiotic susceptibility testing was performed using the K-B method. Of the 2,676 participants, 87 (3.25?%) had a positive B. gladioli blood culture that occurred >72?h after birth, including a premature group (54.0?%, asphyxia [vs. 9.20?%], fever [vs. 13.80?%], pneumonia [vs. 6.90?%] and hyperbilirubinaemia [vs. 8.05?%]) and newborns with necrotising enterocolitis (NEC) (vs. 5.75?%). The mean?±?standard deviation (SD) of the CRP level was 12.31?±-.26?mg/L and that of the PCT level was 1.53?±-.21?ng/ml in the 87 B. gladioli-infected newborns. Most of the B. gladioli isolates were sensitive to many antimicrobial agents and did not lead to serious consequences. All of the B. gladioli-infected newborns were unhealthy, especially the premature infants. B. gladioli might be a causative bacteraemia agent in neonates, it appears to have pathogenic potential in newborns and its sensitivity to antibiotics may be a beneficial factor.