The effects of complex herbal medicine composed of Cornus fructus, Dioscoreae rhizoma, Aurantii fructus, and Mori folium in obese type-2 d

详细信息    查看全文

• 作者：Ki-Suk Kim (1)
  Hea Jung Yang (1)
  Eun-Kyeong Choi (1)
  Min Hee Shin (1)
  Kang-Hoon Kim (1)
  Jae Young Um (1)
  Byung-Cheol Lee (1)
  Hyeung-Jin Jang (1)
  
• 关键词：Diabetes ; GLP ; 1 ; Incretin ; Obesity ; Multiplex
• 刊名：Oriental Pharmacy and Experimental Medicine
• 出版年：2013
• 出版时间：March 2013
• 年：2013
• 卷：13
• 期：1
• 页码：69-75
• 全文大小：289KB
• 参考文献：1. Adam Z, Khamis S, Ismail A, Hamid M (2012) Ficus deltoidea: a potential alternative medicine for diabetes mellitus. Evid Based Complement Alternat Med 2012:632763 CrossRef
  2. Baggio LL, Drucker DJ (2007) Biology of incretins: GLP-1 and GIP. Gastroenterology 132:2131-157 CrossRef
  3. Choi EK, Kim KS, Yang HJ, Shin MH, Suh HW, Lee KB, Ahn KS, Um JY, Lee SG, Lee BC et al (2012) Hexane fraction of / Citrus aurantium L. stimulates glucagon-like peptide-1 (GLP-1) secretion via membrane depolarization in NCI-H716 cells. BioChip J 6:41-7 CrossRef
  4. Dong H, Wang N, Zhao L, Lu F (2012) Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternat Med 2012:591654 CrossRef
  5. Folco EJ, Rocha VZ, Lopez-Ilasaca M, Libby P (2009) Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10. J Biol Chem 284:25569-5575 CrossRef
  6. Ford ES, Giles WH, Dietz WH (2002) Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287:356-59 CrossRef
  7. Han S-R, Paik S-H, Kwon O-J, Ahn Y-M, Lee B-C, Ahn S-Y (2012) Effects in metabolism and adipocyte inflammation induced by the complex herbal medicine composed of / Cornus officinalis, / Dioscorea rhizoma, / Aurantii fructus, / Mori folium in obese type 2 diabetes mouse model. J Korean Oriental Med 33:184-99
  8. Hsu JH, Wu YC, Liu IM, Cheng JT (2007) Dioscorea as the principal herb of Die-Huang-Wan, a widely used herbal mixture in China, for improvement of insulin resistance in fructose-rich chow-fed rats. J Ethnopharmacol 112:577-84 CrossRef
  9. Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M, Taskinen MR, Groop L (2001) Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 24:683-89 CrossRef
  10. James WP, Caterson ID, Coutinho W, Finer N, Van Gaal LF, Maggioni AP, Torp-Pedersen C, Sharma AM, Shepherd GM, Rode RA et al (2010) Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. N Engl J Med 363:905-17 CrossRef
  11. Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, Zhou J, Kim HH, Xu X, Chan SL, Juhaszova M et al (2007) Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A 104:15069-5074 CrossRef
  12. Jung UJ, Lee MK, Jeong KS, Choi MS (2004) The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice. J Nutr 134:2499-503
  13. Kim K-S, Park YJ, Jung H-J, Ahn K-S, Lee S-G, Kim S-H, Jung S-K, Jang H-J (2010) Global transcriptome analysis of the / Escherichia coli O157 response to / Houttuynia Cordata Thunb. BioChip J 4:237-46 CrossRef
  14. Kimura T, Nakagawa K, Kubota H, Kojima Y, Goto Y, Yamagishi K, Oita S, Oikawa S, Miyazawa T (2007) Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 55:5869-874 CrossRef
  15. Kurowska EM, Manthey JA (2004) Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. J Agric Food Chem 52:2879-886 CrossRef
  16. Li WL, Zheng HC, Bukuru J, De Kimpe N (2004) Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol 92:1-1 CrossRef
  17. Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagaretani H, Furuyama N, Kondo H, Takahashi M, Arita Y et al (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8:731-37 CrossRef
  18. Oh KS, Ryu SY, Lee S, Seo HW, Oh BK, Kim YS, Lee BH (2009) Melanin-concentrating hormone-1 receptor antagonism and anti-obesity effects of ethanolic extract from Morus alba leaves in diet-induced obese mice. J Ethnopharmacol 122:216-20 CrossRef
  19. Park JM, Bong HY, Jeong HI, Kim YK, Kim JY, Kwon O (2009) Postprandial hypoglycemic effect of mulberry leaf in Goto-Kakizaki rats and counterpart control Wistar rats. Nutr Res Pract 3:272-78 CrossRef
  20. Park E-Y, Ahn S-Y, Ahn Y-M, Um J-Y, Jang H-J, Lee B-C (2011) The effects of supungsunki-hwan partitioned prescriptions on obese type 2 diabetes mouse model induced by high fat, high carbohydrate diet. Korean J Orient Int Med 32:387-96
  21. Patel A, MacMahon S, Chalmers J, Neal B, Woodward M, Billot L, Harrap S, Poulter N, Marre M, Cooper M et al (2007) Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet 370:829-40 CrossRef
  22. Shin MH, Suh HW, Lee KB, Kim KS, Yang HJ, Choi EK, Cho YJ, Song MY, Ahn KS, Jang HJ (2012) Gentiana scabra extracts stimulate glucagon-like peptide-1 secretion via G protein-coupled receptor pathway. BioChip J 6:114-19 CrossRef
  23. Toft-Nielsen MB, Madsbad S, Holst JJ (2001) Determinants of the effectiveness of glucagon-like peptide-1 in type 2 diabetes. J Clin Endocrinol Metab 86:3853-860 CrossRef
  24. Wang E, Wylie-Rosett J (2008) Review of selected Chinese herbal medicines in the treatment of type 2 diabetes. Diabetes Educ 34:645-54 CrossRef
  25. Yamabe N, Kang KS, Matsuo Y, Tanaka T, Yokozawa T (2007) Identification of antidiabetic effect of iridoid glycosides and low molecular weight polyphenol fractions of Corni Fructus, a constituent of Hachimi-jio-gan, in streptozotocin-induced diabetic rats. Biol Pharm Bull 30:1289-296 CrossRef
  
• 作者单位：Ki-Suk Kim (1)
  Hea Jung Yang (1)
  Eun-Kyeong Choi (1)
  Min Hee Shin (1)
  Kang-Hoon Kim (1)
  Jae Young Um (1)
  Byung-Cheol Lee (1)
  Hyeung-Jin Jang (1)
  
  1. College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, Heogi-dong, Dongdaemun-gu, Seoul, 130-701, Republic of Korea
  
• ISSN：2211-1069

文摘

Prediabetes, Diabetes and obesity are the metabolic diseases which are closely linked each other to its properties such as hypertension, hyperlipidemia, and abdominal obesity. Many studies tried to find single therapeutic target for treatment of the metabolic syndrome but failed because of its side effects. Therefore, many investigations focus on the reduction of the blood glucose or the body weight. Glucagon-like peptide-1 (GLP-1), a new therapeutic target for type-2 diabetes which caused by insulin resistance and relative insulin deficiency, is issued nowadays. This study aimed to investigate the antidiabetic effect of a complex herbal medicine, JUL04, composed of Cornus fructus (CF), Dioscoreae rhizome (DR), Aurantii fructus (AF), and Mori folium (MF), on the enteroendocrine L cell and on the obese type-2 diabetes mice. Fully differentiated NCI-H716 cells were treated with each herbal samples and GLP-1 ELISA was performed. The animal model was induced by high fat- and high sucrose-diet with or without JUL04 for 8?weeks, and the body and the epididymal fat weight and the size of white adipocyte were measured. Plasma GLP-1 and insulin concentration were also measured by ELISA. The results of the study demonstrate that JUL04 has anti-diabetes and anti-obesity effects in high fat- and high sucrose-diet induced mice model.