The frequency of HLA alleles in the Romanian population

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• 作者：Ileana Constantinescu ; Voicu Boșcaiu ; Petru Cianga ; Andrei-Antoniu Dinu…
• 关键词：Human leukocyte antigen (HLA) ; Allele frequency ; HLA polymorphism ; Population studies
• 刊名：Immunogenetics
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：68
• 期：3
• 页码：167-178
• 全文大小：1,255 KB
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• 作者单位：Ileana Constantinescu (1) (2) <br> Voicu Boșcaiu (3) <br> Petru Cianga (4) <br> Andrei-Antoniu Dinu (1) (2) <br> Elena Gai (5) <br> Mihaela Melinte (6) <br> Ana Moise (1) (2) <br><br>1. Department of Transplant Immunology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania <br> 2. Centre for Immunogenetics, Fundeni Clinical Institute, Bucharest, Romania <br> 3. “Gheorghe Mihoc-Caius Iacob” Institute of Mathematical Statistics and Applied Mathematics, Bucharest, Romania <br> 4. Laboratory of Immunology and Genetics, “Sf. Spiridon” Hospital, Iasi, Romania <br> 5. Centre for Immunophysiology and Biotechnology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania <br> 6. Centre for Immunogenetics, Emergency Institute for Cardiovascular Diseases and Transplantation, Targu-Mures, Romania <br>
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine<br>Immunology<br>Allergology<br>Cell Biology<br>
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1211

文摘

Knowledge of human leukocyte antigen (HLA) allele frequencies is essential for bone marrow and kidney donor searches. The Romanian Caucasian population is heterogeneous and information on HLA polymorphism has not been well studied. We characterized the HLA genetic profile and allele frequencies of regional populations in Romania. HLA-A, B and DRB1 alleles were examined in 8252 individuals, belonging to the four main regions of Romania. The most common alleles found in the Romanian population are the following: HLA-A*01, A*02, A*03, A*11, A*24; HLA-B*18, B*35, B*44, B*51 and HLA-DRB1*01, DRB1*03, DRB1*07, DRB1*11, DRB1*13, DRB1*15, DRB1*16. More than half of the alleles are non-homogeneously spread in Romania. These results provide a starting point for future analyses of genetic heterogeneity in Romania.