Probiotics and food allergy
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  • 作者:Anna Maria Castellazzi (4)
    Chiara Valsecchi (4)
    Silvia Caimmi (4)
    Amelia Licari (4)
    Alessia Marseglia (4)
    Maria Chiara Leoni (4)
    Davide Caimmi (4)
    Michele Miraglia del Giudice (4)
    Salvatore Leonardi (4)
    Mario La Rosa (4)
    Gian Luigi Marseglia (4)
  • 关键词:Food allergy ; Probiotics ; Allergic disease ; Intestinal microbiota ; Children
  • 刊名:Italian Journal of Pediatrics
  • 出版年:2013
  • 出版时间:December 2013
  • 年:2013
  • 卷:39
  • 期:1
  • 全文大小:217KB
  • 参考文献:1. Johansson SGO, Hourihane JOB, Bousquet J, Bruijnzeel-Koomen C, Dreborg S, Haahtela T, Kowalski ML, Mygind N, Ring J, van Cauwenberge P, van Hage-Hamsten M, Wuthrich B: A revised nomenclature for allergy. / Allergy 2001, 56:813-24. CrossRef
    2. Cianferoni A, Spergel JM: Food allergy: review, classification and diagnosis. / Allergol Int 2009, 58:457-66. CrossRef
    3. Sicherer SH, Sampson HA: Food allergy: recent advances in pathophysiology and treatment. / Annu Rev Med 2009, 60:261-77. CrossRef
    4. Nowak-Wegrzyn A, Sampson HA: Adverse reactions to foods. / Med Clin North Am 2006, 90:97-27. CrossRef
    5. Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E, Sigurdardottir ST, Lindner T, Goldhahn K, Dahlstrom J, McBride D, Madsen C: The prevalence of food allergy: a meta-analysis. / J Allergy Clin Immunol 2007, 120:638-46. CrossRef
    6. Boyce JA, Assa’ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA Jr, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JM, NIAID-Sponsored Expert Panel: Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. / J Allergy Clin Immunol 2010,126(6):S1-S58. CrossRef
    7. Caffarelli C, Coscia A, Ridolo E, Povesi Dascola C, Gelmetti C, Raggi V, / et al.: Parents’estimate of food allergy in Italian school-aged children. / Ped Int 2011, 53:506-10.
    8. Caffarelli C, Petroccione T: False-negative food challengesin children with suspected food allergy. / Lancet 2001, 358:1871-872. CrossRef
    9. Caffarelli C, Ricò S, Rinaldi L, Povesi Dascola C, Terzi C, Bernasconi S: Blood pressure monitoring in children undergoing food challenge: association with anaphylaxis. / Ann Allergy Asthma Immunol 2012, 108:285-86. CrossRef
    10. Sicherer SH, Sampson HA: Food allergy. / J Allergy Clin Immunol 2010, 125:S116-S125. CrossRef
    11. Cataldo F, Accomando S, Fragapane ML, Montaperto D, SIGENP and GLNBI Working Groups on Food Intolerances: Are food intolerances and allergies increasing in immigrant children coming from developing countries ? / Pediatr Allergy Immunol 2006, 17:364-69. CrossRef
    12. Lee LA, Burks AW: Food allergies: prevalence, molecular characterization, and treatment/prevention strategies. / Annu Rev Nutr 2006, 26:539-65. CrossRef
    13. Vickery BP, Chin S, Burks AW: Pathophysiology of food allergy. / Pediatr Clin North Am 2011, 58:363-76. CrossRef
    14. Waserman S, Watson W: Food allergy. / Allergy Asthma Clin Immunol 2011, 7:S7. CrossRef
    15. Mowat AM: Anatomical basis of tolerance and immunity to intestinal antigens. / Nat Rev Immunol 2003, 3:331-41. CrossRef
    16. Povesi-Dascola C, Caffarelli C: Exercise-induced anaphylaxis: a clinical view. / Ital J Ped 2012, 38:43. CrossRef
    17. Caffarelli C, Cataldi R, Giordano S, Cavagni G: Anaphylaxis induced by exercise and related to multiple food intake. / Allergy Asthma Proc 1997, 18:245-48. CrossRef
    18. Dahan S, Roth-Walter F, Arnaboldi P, Agarwal S, Mayer L: Epithelia: lymphocyte interactions in the gut. / Immunol Rev 2007, 215:243-53. CrossRef
    19. Leonardi S, Miraglia del Giudice M, La Rosa M, Bellanti JA: Atopic disease, immune system, and the environment. / Allergy Asthma Proc 2007, 28:410-17. CrossRef
    20. Sampson HA: Update on food allergy. / J Allergy Clin Immunol 2004, 113:805-19. CrossRef
    21. Miraglia del Giudice M, De Luca M: The role of probiotics in the clinical management of food allergy and atopic dermatitis. / Journal of Clinical Gastr 2004, 38:84-5. ISSN: 0192-790 CrossRef
    22. Caffarelli C, Baldi F, Bendandi B, Calzone L, Marani M, Pasquinelli P, on behalf of EWGPAG: Cow’s milk protein allergy in children: a practical guide. / Ital J Pediatr 2010, 36:5. CrossRef
    23. Mevissen-Verhage EA, Marcelis JH, Harmsen-Van Amerongen WC, de Vos NM, Verhoef J: Effect of iron on neonatal gut flora during the first three months of life. / Eur J Clin Microbiol 1985, 4:273-78. CrossRef
    24. Laparra JM, Sanz Y: Interactions of gut microbiota with functional food components and nutraceuticals. / Pharmacol Res 2010, 61:219-25. CrossRef
    25. Caffarelli C, Cavagni G, Pierdomenico R, Chiari G, Spattini A, Vanelli M: Coexistence of IgE-mediated allergy and type 1 diabetes in childhood. / Int Arch Allergy Immunol 2004, 134:288-94. CrossRef
    26. Holt PG, Sly PD, Bj?rkstén B: Atopic versus infectious diseases in childhood: a question of balance? / Pediatr Allergy Immunol 1997, 8:53-8. CrossRef
    27. Aureli P, Capurso L, Castellazzi AM, Clerici M, Giovannini M, Morelli L, Poli A, Pregliasco F, Salvini F, Zuccotti GV: Probiotics and health: an evidence-based review. / Pharmacol Res 2011, 63:366-76. CrossRef
    28. Vitaliti G, Leonardi S, Miraglia Del Giudice M, Salpietro A, Artusio L, Caimmi D, Arrigo T, Salpietro C, Ciprandi G, La Rosa M: Mucosal immunity and sublingual immunotherapy in respiratory disorders. / J Biol Regul Homeost Agents 2012,26(1):S85-S93.
    29. Miraglia Del Giudice M, Marseglia GL, Leonardi S, Tosca MA, Marseglia A, Perrone L, Ciprandi G: Fractional exhaled nitric oxide measurements in riniti and asthma in children. / Int J Immunopathol Pharmacol 2011,24(4 Suppl):29-2.
    30. Leonardi S, Vitaliti G, Marseglia GL, Caimmi D, Lionetti E, Miraglia Del Giudice M, Salpietro C, Spicuzza L, Ciprandi G, La Rosa M: Function of the airway epithelium in asthma. / J Biol Regul Homeost Agents 2012,26(1):S41-S48.
    31. Bancroft AJ, Hayes KS, Grencis RK: Life on the edge: the balance between macrofauna, microflora and host immunity. / Trends Parasitol 2012, 28:93-8. CrossRef
    32. Bj?rkstén B, Naaber P, Sepp E, Mikelsaar M: The intestinal microflora in allergic Estonian and Swedish 2-year-old children. / Clin Exp Allergy 1999, 29:342-46. CrossRef
    33. Sj?gren YM, Jenmalm MC, B?ttcher MF, Bj?rkstén B, Sverremark-Ekstr?m E: Altered early infant gut microbiota in children developing allergy up to 5 years of age. / Clin Exp Allergy 2009, 39:518-26. CrossRef
    34. / Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. 2001. http://www.fao.org
    35. Ministero della Salute Italiano: / Linee guida probiotici e prebiotici. Lungotevere Ripa 1- 00153 Roma Italy: Ministero della Salute; 2005.
    36. EFSA: / EFSA Scientific Colloquium Summary Report. QPS: qualified presumption of safety of microrganisms in food and feed. via Carlo Magno 1A- 43126 Parma, Italy: EFSA (Autorità Europea Sicurezza Alimentare); 2004.
    37. Iannitti T, Palmieri B: Therapeutical use of probiotic formulations in clinical practice. / Clin Nutr 2010, 29:701-25. CrossRef
    38. Snydman DR: The safety of probiotics. / Clin Infect Dis 2008, 46:S104-S111. CrossRef
    39. Wassenaar TM, Klein G: Safety aspects and implications of regulation of probiotic bacteria in food and food supplements. / J Food Prot 2008, 71:1734-741.
    40. Liong MT: Safety of probiotics: translocation and infection. / Nutr Rev 2008, 66:192-02. CrossRef
    41. Zeuthen LH, Fink LN, Frokiaer H: Epithelial cells prime the immune response to an array of gut-derived commensals towards a tolerogenic phenotype through distinct actions of thymic stromal lymphopoietin and transforming growth factor-beta. / Immunology 2008, 123:197-08.
    42. Mohamadzadeh M, Olson S, Kalina WV, Ruthel G, Demmin GL, Warfield KL, Bavari S, Klaenhammer TR: Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization. / Proc Natl Acad Sci USA 2005, 102:2880-885. CrossRef
    43. Rizzello V, Bonaccorsi I, Dongarrà ML, Fink LN, Ferlazzo G: Role of natural killer and dendritic cell crosstalk in immunomodulation by commensal bacteria probiotics. / J Biomed Biotechnol 2011, 2011:473097. CrossRef
    44. Salpietro C, Rigoli L, Miraglia Del Giudice M, Cuppari C, Di Bella C, Salpietro A, Maiello N, La Rosa M, Marseglia GL, Leonardi S, Briuglia S, Ciprandi G: TLR2 and TLR4 gene polymorphisms and atopic dermatitis in Italian children: a multicenter study. / Int J Immunopathol Pharmacol 2011,24(4 Suppl):33-0.
    45. Smits HH, van Beelen AJ, Hessle C, Westland R, de Jong E, Soeteman E, Wold A, Wierenga EA, Kapsenberg ML: Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development. / Eur J Immunol 2004, 34:1371-380. CrossRef
    46. Rachmilewitz D, Katakura K, Karmeli F, Hayashi T, Reinus C, Rudensky B, Akira S, Takeda K, Lee J, Takabayashi K, Raz E: Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. / Gastroenterology 2004, 126:520-28. CrossRef
    47. Iliev ID, Tohno M, Kurosaki D, Shimosato T, He F, Hosoda M, Saito T, Kitazawa H: Immunostimulatory oligodeoxynucleotide containing TTTCGTTT motif from Lactobacillus rhamnosus GG DNA potentially suppresses OVA-specific IgE production in mice. / Scand J Immunol 2008, 67:370-76. CrossRef
    48. Iliev ID, Kitazawa H, Shimosato T, Katoh S, Morita H, He F, Hosoda M, Saito T: Strong immunostimulation in murine immune cells by Lactobacillus rhamnosus GG DNA containing novel oligodeoxynucleotide pattern. / Cell Microbiol 2005, 7:403-14. CrossRef
    49. Perdigon G, Alvarez S, Medina M, Vinti?i E, Roux E: Influence of the oral administration of lactic acid bacteria on IgA producing cells associated to bronchus. / Int J Immunopathol Pharmacol 1999.
    50. Lee J, Seto D, Bielory L: Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis. / J Allergy Clin Immunol 2008, 121:116-21. CrossRef
    51. Del Giudice MM, Decimo F, Leonardi S, Maioello N, Amelio R, Capasso A, Capristo C, Capristo AF: Immune dysregulation in atopic dermatitis. / Allergy Asthma Proc 2006,27(6):451-55. CrossRef
    52. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, Zuberbier T, Baena-Cagnani CE, Canonica GW, van Weel C, Agache I, A?t-Khaled N, Bachert C, Blaiss MS, Bonini S, Boulet LP, Bousquet PJ, Camargos P, Carlsen KH, Chen Y, Custovic A, Dahl R, Demoly P, Douagui H, Durham SR, van Wijk RG, Kalayci O, Kaliner MA, Kim YY, Kowalski ML, / et al.: GA(2)LEN; AllerGen. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA (2) LEN and AllerGen). / Allergy 2008, 63:S8-S160. CrossRef
    53. Linneberg A, Henrik Nielsen N, Fr?lund L, Madsen F, Dirksen A, J?rgensen T: Copenhagen Allergy Study. The link between allergic rhinitis and allergic asthma: a prospective population-based study. The Copenhagen Allergy Study. / Allergy 2002, 57:1048-052. CrossRef
    54. Miraglia del Giudice M, Rocco A, Capristo C: Probiotics in the atopic march: highlights and new insights. / Dig Liver Dis 2006, 38:288-90. CrossRef
    55. Majamaa H, Isolauri E: Probiotics: a novel approach in the management of food allergy. / J Allergy Clin Immunol 1997, 99:179-85. CrossRef
    56. Del Giudice MM, Leonardi S, Maiello N, Brunese FP: Food allergy and probiotics in childhood (Conference Paper). / J.Clin.Gastr 2010,44(1):S22-S25. CrossRef
    57. Smehilová M, Vlková E, Nevoral J, Flajsmanová K, Killer J, Rada V: Comparison of intestinal microflora in healthy infants and infants with allergic colitis. / Folia Microbiol (Praha) 2008, 53:255-58. CrossRef
    58. Caffarelli C, Bernasconi S: Preventing necrotising enetrocolitis with probiotics. / Lancet 2007, 369:1578-580. CrossRef
    59. Woodcock A, Moradi M, Smillie FI, Murray CS, Burnie JP, Custovic A: Clostridium difficile, atopy and wheeze during the first year of life. / Pediatr Allergy Immunol 2002, 13:357-60. CrossRef
    60. Giovannini M, Agostoni C, Riva E, Salvini F, Ruscitto A, Zuccotti GV, Radaelli G, Felicita Study Group: A randomized prospective double blind controlled trial on effects of long-term consumption of fermented milk containing Lactobacillus casei in pre-school children with allergic asthma and/or rhinitis. / Pediatr Res 2007, 62:215-20. CrossRef
    61. Kalliom?ki M, Kirjavainen P, Eerola E, Kero P, Salminen S, Isolauri E: Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. / J Allergy Clin Immunol 2001, 107:129-34. CrossRef
    62. Kalliom?ki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E: Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. / Lancet 2001, 357:1076-079. CrossRef
    63. Grüber C: Probiotics and prebiotics in allergy prevention and treatment: future prospects. / Expert Rev Clin Immunol 2012, 8:17-9. CrossRef
    64. Kopp MV, Hennemuth I, Heinzmann A, Urbanek R: Randomized, double-blind, placebo-controlled trial of probiotics for primary prevention: no clinical effects of Lactobacillus GG supplementation. / Pediatrics 2008, 121:e850-e856. CrossRef
    65. Doege K, Grajecki D, Zyriax BC, Detinkina E, Zu Eulenburg C, Buhling KJ: Impact of maternal supplementation with probiotics during pregnancy on atopic eczema in childhood -a meta-analysis. / Br J Nutr 2012, 107:1-. CrossRef
    66. Kuitunen M, Kukkonen K, Juntunen-Backman K, Korpela R, Poussa T, Tuure T, Haahtela T, Savilahti E: Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort. / J Allergy Clin Immunol 2009, 123:335-41. CrossRef
    67. Wickens K, Black PN, Stanley TV, Mitchell E, Fitzharris P, Tannock GW, Purdie G, Crane J, Probiotic Study Group: A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial. / J Allergy Clin Immunol 2008, 122:788-94. CrossRef
    68. Huurre A, Laitinen K, Rautava S, Korkeam?ki M, Isolauri E: Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double-blind placebo-controlled study. / Clin Exp Allergy 2008, 38:1342-348. CrossRef
    69. Abrahamsson TR, Jakobsson T, B?ttcher MF, Fredrikson M, Jenmalm MC, Bj?rkstén B, Oldaeus G: Probiotics in prevention of IgE-associated eczema: a double-blind, randomized, placebo-controlled trial. / J Allergy Clin Immunol 2007, 119:1174-180. CrossRef
    70. Kalliom?ki M, Salminen S, Poussa T, Isolauri E: Probiotics during the first 7 years of life: a cumulative risk reduction of eczema in a randomized, placebo-controlled trial. / J Allergy Clin Immunol 2007, 119:1019-021. CrossRef
    71. Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, Tuure T, Kuitunen M: Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. / J Allergy Clin Immunol 2007, 119:192-98. CrossRef
    72. Ismail IH, Oppedisano F, Joseph SJ, Boyle RJ, Robins-Browne RM, Tang ML: Prenatal administration of Lactobacillus rhamnosus has no effect on the diversity of the early infant gut microbiota. / Pediatr Allergy Immunol 2011.
    73. Drago L, Iemoli E, Rodighiero V, Nicola L, De Vecchi E, Piconi S: Effects of Lactobacillus salivarius LS01 (DSM 22775) treatment on adult atopic dermatitis: a randomized placebo-controlled study. / Int J Immunopathol Pharmacol 2011, 24:1037-048.
    74. Johannsen H, Prescott SL: Practical prebiotics, probiotics and synbiotics for allergists: how useful are they? / Clin Exp Allergy 2009, 39:1801-814. CrossRef
    75. Gore C, Custovic A, Tannock GW, Munro K, Kerry G, Johnson K, Peterson C, Morris J, Chaloner C, Murray CS, Woodcock A: Treatment and secondary prevention effects of the probiotics Lactobacillus paracasei or Bifidobacterium lactis on early infant eczema: randomized controlled trial with follow-up until age 3 years. / Clin Exp Allergy 2012, 42:112-22. CrossRef
    76. Wu KG, Li TH, Peng HJ: Lactobacillus salivarius plus fructo-oligosaccharide is superior to fructo-oligosaccharide alone for treating children with moderate to severe atopic dermatitis: a double-blind, randomized, clinical trial of efficacy and safety. / Br J Dermatol 2012, 166:129-36. CrossRef
    77. Del Giudice MM, Leonardi S, Ciprandi G, Galdo F, Gubitosi A, La Rosa M, Salpietro C, Marseglia G, Perrone L: Probiotics in childhood: Allergic illness and respiratory infections J. / Clinical Gastroenterology 2012,46(SUPPL. 1):S69-S72. CrossRef
    78. Castellazzi AM, Valsecchi C, Montagna L, Malfa P, Ciprandi G, Avanzini MA, Marseglia GL: In vitro activation of mononuclear cells by two probiotics: lactobacillus paracasei I 1688, Lactobacillus salivarius I 1794, and their mixture (PSMIX). / Immunol Invest 2007, 36:413-21. CrossRef
    79. Vliagoftis H, Kouranos VD, Betsi GI, Falagas ME: Probiotics for the treatment of allergic rhinitis and asthma: systematic review of randomized controlled trials. / Ann Allergy Asthma Immunol 2008, 101:570-79. CrossRef
    80. Rose MA, Stieglitz F, K?ksal A, Schubert R, Schulze J, Zielen S: Efficacy of probiotic Lactobacillus GG on allergic sensitization and asthma in infants at risk. / Clin Exp Allergy 2010, 40:1398-405. CrossRef
    81. Jan RL, Yeh KC, Hsieh MH, Lin YL, Kao HF, Li PH, Chang YS, Wang JY: Lactobacillus gasseri suppresses Th17 pro-inflammatory response and attenuates allergen-induced airway inflammation in a mouse model of allergic asthma. / Br J Nutr 2012 Jul 14,108(1):130-39. CrossRef
    82. Zuercher AW, Weiss M, Holvoet S, Moser M, Moussu H, van Overtvelt L, Horiot S, Moingeon P, Nutten S, Prioult G, Singh A, Mercenier A: Lactococcus lactis NCC 2287 alleviates food allergic manifestations in sensitized mice by reducing IL-13 expression specifically in the ileum. / Clin Dev Immunol 2012, 2012:485750. CrossRef
    83. Schiavi E, Barletta B, Butteroni C, Corinti S, Boirivant M, Di Felice G: Oral therapeutic administration of a probiotic mixture suppresses established Th2 responses and systemic anaphylaxis in a murine model of food allergy. / Allergy 2011, 66:499-08. CrossRef
    84. Kuitunen M: Probiotics and Prebiotics in Preventing Food Allergy and Eczema. / Curr Opin Allergy Clin Immunol 2013,13(3):280-86.
    85. Burks AW, Calderon MA, Casale T, Cox L, Demoly P, Jutel M, Nelson H, Akdis CA: Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report. / J Allergy Clin Immunol 2013,131(5):1288-296. CrossRef
  • 作者单位:Anna Maria Castellazzi (4)
    Chiara Valsecchi (4)
    Silvia Caimmi (4)
    Amelia Licari (4)
    Alessia Marseglia (4)
    Maria Chiara Leoni (4)
    Davide Caimmi (4)
    Michele Miraglia del Giudice (4)
    Salvatore Leonardi (4)
    Mario La Rosa (4)
    Gian Luigi Marseglia (4)

    4. Department of Medical and Pediatric Science, University of Catania, Catania, Italy
文摘
The exact prevalence of food allergy in the general population is unknown, but almost 12% of pediatric population refers a suspicion of food allergy. IgE mediated reactions to food are actually the best-characterized types of allergy, and they might be particularly harmful especially in children. According to the “hygiene hypothesis-low or no exposure to exogenous antigens in early life may increase the risk of allergic diseases by both delaying the development of the immune tolerance and limiting the Th2/Th1 switch. The critical role of intestinal microbiota in the development of immune tolerance improved recently the interest on probiotics, prebiotics, antioxidants, polyunsaturated fatty acid, folate and vitamins, which seem to have positive effects on the immune functions. Probiotics consist in bacteria or yeast, able to re-colonize and restore microflora symbiosis in intestinal tract. One of the most important characteristics of probiotics is their safety for human health. Thanks to their ability to adhere to intestinal epithelial cells and to modulate and stabilize the composition of gut microflora, probiotics bacteria may play an important role in the regulation of intestinal and systemic immunity. They actually seem capable of restoring the intestinal microbic equilibrium and modulating the activation of immune cells. Several studies have been recently conducted on the role of probiotics in preventing and/or treating allergic disorders, but the results are often quite contradictory, probably because of the heterogeneity of strains, the duration of therapy and the doses administered to patients. Therefore, new studies are needed in order to clarify the functions and the utility of probiotics in food allergies and ion other types of allergic disorders.

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