Effects of herb-partitioned moxibustion and electroacupuncture on serum indexes of intestinal fibrosis in rats with Crohn’s disease

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• 作者：Yanbo Ren (1)
  Cuihong Zhang (1)
  Caiping An (2)
  Huangan Wu (1)
  Jue Hong (1)
  Lingxiang Wu (1)
  Jie Liu (1)
  Xiaopeng Ma (1)
  
• 关键词：Indirect Moxibustion ; Electroacupuncture ; Crohn Disease ; Fibrosis ; Serology ; /li> ; ; /li> ; R246.1
• 刊名：Journal of Acupuncture and Tuina Science
• 出版年：2011
• 出版时间：February 2011
• 年：2011
• 卷：9
• 期：1
• 页码：13-16
• 全文大小：293KB
• 参考文献：1. Wu XN, Liu AQ. Detection, meaning and cause of intestinal fibrosis in Crohn’s disease. Chinese Journal of Digestion, 2007, 27(3): 210-11.
  2. Pohlers D, Brenmoehl J, Lffler I, Müller CK, Leipner C, Schultze-Mosgau S, Stallmach A, Kinne RW, Wolf G. TGF-beta and fibrosis in different organs-molecular pathway imprints. Biochim Biophys Acta, 2009, 1793(8): 746-56.
  3. Ngo P, Ramalingam P, Phillips JA, Furuta GT. Collagen gel contraction assay. Methods Mol Biol, 2006, 341: 103-09.
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  7. Vallance BA, Gunawan MI, Hewlett B, Bercik P, Van Kampen C, Galeazzi F, Sime PJ, Gauldie J, Collins SM. TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis. Am J Physiol Gastrointest Liver Physiol, 2005, 289(1): G116–G128. CrossRef
  8. Joos S, Brinkhaus B, Maluche C, Maupai N, Kohnen R, Kraehmer N, Hahn EG, Schuppan D. Acupuncture and moxibustion in the treatment of active Crohn’s disease: a randomized controlled study. Digestion, 2004, 69(3): 131-39. CrossRef
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  10. Yu WH, Xu GQ. Mechanism of fibrosis and the change of serum fibrostic markers in Crohn’s disease. International Journal of Digestive Diseases 2009, 29(4): 235-63.
  
• 作者单位：Yanbo Ren (1)
  Cuihong Zhang (1)
  Caiping An (2)
  Huangan Wu (1)
  Jue Hong (1)
  Lingxiang Wu (1)
  Jie Liu (1)
  Xiaopeng Ma (1)
  
  1. Shanghai Research Institute of Acupuncture and Meridian, Shanghai, 200030, P. R. China
  2. Maternity Hospital, Fudan University, Shanghai, 200011, P. R. China
  

文摘

Objective To observe the impact of herb-partitioned moxibustion and electroacupuncture on hyaluronic acid (HA), procollagen III (PC III) and collagen IV (C IV) of intestinal fibrosis in rats with Crohn’s disease (CD), and discuss the effect and the mechanism of acupuncture on treating intestinal fibrosis of rats. Methods SD rats were randomly divided into control group, model group, herb-partitioned moxibustion group, electroacupuncture group and medicine group. The model of CD was developed by trinitrobenzene sulfonic acid. Masson stain was used to observe the collagen fibers hyperplasia in colon and radioimmunoassay was adopted to detect the content of HA, PC III and C IV in serum. Results Compared with the control group, the proliferation of colonic collagen fibers, as well as the HA, PC III and C IV in serum increased in the model group. Compared with the model group, the expression of collagen fibers, serum HA, PC III and C IV decreased in the herb-partitioned moxibustion group, electroacupuncture group and medicine group. The expression of collagen fibers serum HA, PC III and C IV in the herb-partitioned moxibustion group were lower than in the electroacupuncture group and medicine group. Conclusion Herb-partitioned moxibustion and electroacupuncture effectively improved the pathological state of intestinal fibrosis in rats with CD and reduced the content of HA, PC III and C IV in serum.