Determination of 241Am in urine using sector field inductively coupled plasma mass spectrometry (SF-ICP-MS)

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• 作者：Ge Xiao (1)
  David Saunders (1)
  Robert L. Jones (1)
  Kathleen L. Caldwell (1)
  
• 关键词：241Am determination ; Solid phase extraction (Eichrom DGA cartridge) ; Sector field inductively coupled plasma mass spectrometer (SF ; ICP ; MS) ; Clinical decision guide (CDG) ; Emergency response
• 刊名：Journal of Radioanalytical and Nuclear Chemistry
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：301
• 期：1
• 页码：285-291
• 全文大小：
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• 作者单位：Ge Xiao (1)
  David Saunders (1)
  Robert L. Jones (1)
  Kathleen L. Caldwell (1)
  
  1. Inorganic and Radiation Analytical Toxicology Branch, Centers for Disease Control and Prevention, 4770 Buford HWY, Mail Stop F50, Atlanta, GA, 30341, USA
  
• ISSN：1588-2780

文摘

Quantification of 241Am in urine at low levels is important for assessment of individuals-or populations-accidental, environmental, or terrorism-related internal contamination, but no convenient, precise method has been established to rapidly determine these low levels. Here we report a new analytical method to measure 241Am as developed and validated at the Centers for Disease Control and Prevention (CDC) by means of the selective retention of Am from urine directly on DGA resin, followed by SF-ICP-MS detection. The method provides rapid results with a limit of detection (LOD) of 0.22?pg/L (0.028?Bq/L), which is lower than 1/3 of the C/P CDG for 241Am at 5?days post-exposure. The results obtained by this method closely agree with CDC values as measured by liquid scintillation counting, and with National Institute of Standards Technology (NIST) Certified Reference Materials (CRM) target values.