A phase II study of Epirubicin in oxaliplatin-resistant patients with metastatic colorectal cancer and TOP2A gene amplification

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• 作者：Line S. Tarpgaard ; Camilla Qvortrup ; Sune B. Nygård ; Signe L. Nielsen…
• 刊名：BMC Cancer
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：16
• 期：1
• 全文大小：426 KB
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• 作者单位：Line S. Tarpgaard (1)
  Camilla Qvortrup (1)
  Sune B. Nygård (2) (3)
  Signe L. Nielsen (2)
  Diana R. Andersen (1)
  Niels Frank Jensen (2)
  Jan Stenvang (2)
  Sönke Detlefsen (4)
  Nils Brünner (2)
  Per Pfeiffer (1)
  
  1. Department of Oncology, Odense University Hospital, Odense, Denmark
  2. Faculty of Health and Medical Sciences, Department of Veterinary Disease Biology, University of Copenhagen, Frederiksberg, Denmark
  3. Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  4. Department of Pathology, Odense University Hospital, Odense, Denmark
  
• 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2407

文摘

ᅟ The overall purpose of this study is to provide proof of concept for introducing the anthracycline epirubicin as an effective, biomarker-guided treatment for metastatic colorectal cancer (mCRC) patients who are refractory to treatment with oxaliplatin-based chemotherapy and have TOP2A gene amplification in their tumor cells.