Cancer: Bad luck or punishment?

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• 作者：A. V. Lichtenstein
• 关键词：cancer ; bad luck hypothesis ; carcinogenesis ; mutagenesis ; extrinsic and intrinsic causes of cancer ; cancer prevention
• 刊名：Biochemistry (Moscow)
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：82
• 期：1
• 页码：75-80
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biochemistry, general; Bioorganic Chemistry; Microbiology; Biomedicine, general;
• 出版者：Pleiades Publishing
• ISSN：1608-3040
• 卷排序：82

文摘

Contrasting opinions on the role of extrinsic and intrinsic factors in cancer etiology (Tomasetti, C., and Vogelstein, B. (2015) Science, 347, 78-81; Wu, S., et al. (2016) Nature, 529, 43-47) variously define priorities in the war on cancer. The correlation between the lifetime risk of several types of cancer and the total number of divisions of normal selfrenewing cells revealed by the authors has given them grounds to put forward the “bad luck” hypothesis. It assumes that ~70% of cancer variability is attributed to random errors arising during DNA replication in normal, noncancerous stem cells, i.e. to internal factors, which is impossible either to expect or to prevent. This assumption caused many critical responses that emphasize, on the contrary, the defining role of extrinsic factors in cancer etiology. The analysis of epidemio-logical and genetic data presented in this work testifies in favor of the “bad luck” hypothesis.