Pandemic Influenza A (H1N1) in Non-vaccinated, Pregnant Women in Spain (2009-010)
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  • 作者：María Morales-Suárez-Varela (1) (2) (3)
    Fernando González-Candelas (2) (3) (4)
    Jenaro Astray (5)
    Jordi Alonso (2) (6) (7)
    Ady Castro (8)
    Rafael Cantón (2) (9)
    Juan Carlos Galán (2) (7)
    Olatz Garin (2) (6)
    Núria Soldevila (2)
    Maretva Baricot (2)
    Jesús Castilla (11) (2)
    Pere Godoy (12) (2)
    Miguel Delgado-Rodríguez (13) (2)
    Vicente Martín (14) (2)
    José María Mayoral (15)
    Tomás Pumarola (16)
    José Maria Quintana (17) (2)
    Sonia Tamames (18)
    Agustín Llopis-González (1) (2) (3)
    ángela Domínguez (19) (2)
  • 关键词：Influenza A (H1N1) ; Pregnancy ; Pandemic ; Symptomatology ; Clinical characteristics
  • 刊名：Maternal and Child Health Journal
  • 出版年：2014
  • 出版时间：August 2014
  • 年：2014
  • 卷：18
  • 期：6
  • 页码：1454-1461
  • 全文大小：189 KB
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  • 作者单位：María Morales-Suárez-Varela (1) (2) (3)
    Fernando González-Candelas (2) (3) (4)
    Jenaro Astray (5)
    Jordi Alonso (2) (6) (7)
    Ady Castro (8)
    Rafael Cantón (2) (9)
    Juan Carlos Galán (2) (7)
    Olatz Garin (2) (6)
    Núria Soldevila (2)
    Maretva Baricot (2)
    Jesús Castilla (11) (2)
    Pere Godoy (12) (2)
    Miguel Delgado-Rodríguez (13) (2)
    Vicente Martín (14) (2)
    José María Mayoral (15)
    Tomás Pumarola (16)
    José Maria Quintana (17) (2)
    Sonia Tamames (18)
    Agustín Llopis-González (1) (2) (3)
    ángela Domínguez (19) (2)

    1. Unit of Public Health and Environmental Care, Department of Preventive Medicine, University of Valencia, Avda. Vicent Andrés Estellés, s/n, 46100, Burjassot, Valencia, Spain
    2. CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain
    3. Center for Public Health Research (CSISP), Valencia, Spain
    4. Research Unit in “Genomics and Health- CSISP, University of Valencia, Burjassot, Spain
    5. Subdirección de Vigilancia, Comunidad de Madrid, Madrid, Spain
    6. Universitat Pompeu Fabra, Barcelona, Spain
    7. IMIM-Institut de Recerca de l’Hospital del Mar, Barcelona, Spain
    8. CIBER Enfermedades Respiratorias, Madrid, Spain
    9. Hospital Universitario Ramón y Cajal, Madrid, Spain
    11. Instituto de Salud Pública de Navarra, Pamplona, Spain
    12. Departament de Salut, Generalitat de Catalunya, Barcelona, Spain
    13. Universidad de Jaén, Jaén, Spain
    14. Universidad de León, León, Spain
    15. Servicio de Vigilancia de Andalucía, Seville, Spain
    16. Red Espa?ola de Investigación en Patología Infecciosa (REIPI), Barcelona, Spain
    17. Fundación Vasca de Innovación e Investigación Sanitarias, Sondika Bizkaia, Spain
    18. Dirección General de Salud Pública, Desarrollo e Innovación, Junta de Castilla y León, Valladolid, Spain
    19. Department of Public Health, University of Barcelona, Barcelona, Spain
  • ISSN：1573-6628
文摘
The aim of this study was to investigate the main characteristics of non-vaccinated pregnant women who were hospitalised for influenza A (H1N1) pdm09 pandemic versus pregnant women hospitalised for non-influenza-related reasons in Spain, and to characterise the clinical presentation of the disease in this population to facilitate early diagnosis and future action programmes. Understanding influenza infection during pregnancy is important as pregnant women are a high-risk population for increased morbidity from influenza infection. We investigated the socio-demographic and clinical features of 51 non-vaccinated, pregnant women infected with the pandemic influenza A (H1N1) virus in Spain (cases) and compared them to 114 controls (non-vaccinated and non-infected pregnant women) aged 15-4?years. Substantial and significant odd ratios (ORs) for pandemic influenza A (H1N1) were found for the pregnant women who were obese compared with controls (body mass index?>?30) (OR 3.03; 95?% confidence intervals 1.13-.11). The more prevalent symptoms observed in pandemic influenza-infected pregnant women were high temperature, cough (82.4?%), malaise (80.5?%), myalgia (56.1?%), and headaches (54.9?%). Our results suggest that the initial symptoms and risk factors for infection of pregnant women with the influenza A (H1N1) pdm09 virus are similar to the symptoms and risk factors for seasonal influenza, which make early diagnosis difficult, and reinforces the need to identify and protect high-risk groups.

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