Serpentine and leading-edge capillary pumps for microfluidic capillary systems

详细信息    查看全文

• 作者：Roozbeh Safavieh (1) (2)
  Ali Tamayol (1) (2) (3) (4)
  David Juncker (1) (2) (5)
  
  1. McGill University and Genome Quebec Innovation Centre ; McGill University ; 740 Dr. Penfield Avenue ; Montreal ; QC ; H3A 0G1 ; Canada
  2. Biomedical Engineering Department ; McGill University ; 3775 University Avenue ; Montreal ; QC ; H3A 2B4 ; Canada
  3. Harvard-MIT Division of Health Sciences and Technology ; Cambridge ; MA ; USA
  4. Harvard Medical School ; Boston ; MA ; USA
  5. Department of Neurology and Neurosurgery ; McGill University ; 3801 University Street ; Montreal ; QC ; H3A 2B4 ; Canada
  
• 关键词：Capillary flow ; Passive pumping ; Microfluidics ; Pore network modeling ; Point ; of ; care
• 刊名：Microfluidics and Nanofluidics
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：18
• 期：3
• 页码：357-366
• 全文大小：2,173 KB
• 参考文献：1. Akbari, M, Sinton, D, Bahrami, M (2009) Pressure drop in rectangular microchannels as compared with theory based on arbitrary cross section. J Fluids Eng 131: pp. 041202 CrossRef
  2. Bracke, M, Devoeght, F, Joos, P (1989) The kinetics of wetting鈥攖he dynamic contact angle. Trends Colloid Interface Sci 79: pp. 142-149
  3. Cesaro-Tadic, S, Dernick, G, Juncker, D, Buurman, G, Kropshofer, H, Michel, B (2004) High-sensitivity miniaturized immunoassays for tumor necrosis factor a using microfluidic systems. Lab Chip 4: pp. 563-569 CrossRef
  4. Chapuis O, Prat M (2007) Influence of wettability conditions on slow evaporation in two-dimensional porous media. Phys Rev E 75:046311-1鈥?46311-5
  5. Delamarche, E, Bernard, A, Schmid, H, Michel, B, Biebuyck, H (1997) Patterned delivery of immunoglobulins to surfaces using microfluidic networks. Science 276: pp. 779-781 CrossRef
  6. Delamarche, E, Bernard, A, Schmid, H, Bietsch, A, Michel, B, Biebuyck, H (1998) Microfluidic networks for chemical patterning of substrate: design and application to bioassays. JACS 120: pp. 500-508 CrossRef
  7. Delamarche, E, Juncker, D, Schmid, H (2005) Microfluidics for processing surfaces and miniaturizing biological assays. Adv Mater 17: pp. 2911-2933 CrossRef
  8. Gervais, L, Delamarche, E (2009) Toward one-step point-of-care immunodiagnostics using capillary-driven microfluidics and PDMS substrates. Lab Chip 9: pp. 3330-3337 CrossRef
  9. Gervais, L, Rooij, N, Delamarche, E (2011) Microfluidic chips for point-of-care immunodiagnostics. Adv Mater 23: pp. H151-H176 CrossRef
  10. Gervais, L, Hitzbleck, M, Delamarche, E (2011) Capillary-driven multiparametric microfluidic chips for one-step immunoassays. Biosens Bioelectron 27: pp. 64-70 CrossRef
  11. Groll, M, Schneider, M, Sartre, V, Zaghdoudi, MC, Lallemand, M (1998) Thermal control of electronic equipment by heat pipes. Rev Gen Therm 37: pp. 323-352 CrossRef
  12. Hassanizadeh, SM, Gray, WG (1993) Thermodynamic basis of capillary pressure in porous media. Water Resour Res 29: pp. 3389-3405 CrossRef
  13. Hitzbleck, M, Gervais, L, Delamarche, E (2011) Controlled release of reagents in capillary-driven microfluidics using reagent integrators. Lab Chip 11: pp. 2680-2685 CrossRef
  14. Ho, C, Ruehli, A, Brennan, P (1975) The modified nodal approach to network analysis. IEEE Trans Circuits Syst 22: pp. 504-509 CrossRef
  15. Hoffman, RL (1982) A study of the advancing interface.2. The theoretical prediction of the dynamic contact angle in liquid gas systems. J Rheol 26: pp. 606
  16. Juncker, D, Schmid, H, Drechsler, U, Wolf, H, Wolf, M, Michel, B (2002) Autonomous microfluidic capillary system. Anal Chem 74: pp. 6139-6144 CrossRef
  17. Lee A (2010) VirtualDub. In: VirtualDubMod Surround 1.6.0.0 (ed)
  18. Leverett, MC (1941) Capillary behavior in porous solids. Trans Am Inst Min Metall Eng 142: pp. 152-169
  19. Lovchik, RD, Bianco, F, Tonna, N, Ruiz, A, Matteoli, M, Delamarche, E (2010) Overflow microfluidic networks for open and closed cell cultures on chip. Anal Chem 82: pp. 3936-3942 CrossRef
  20. McNeely, MR, Spute, MK, Tusneem, NA, Oliphant, AR Hydrophobic microfluidics. In: Ahn, CH, Frazier, AB eds. (1999) Microfluidic devices and systems. Spie-Int Soc Optical Engineering, Bellingham, pp. 210-220 CrossRef
  21. Mirzaei, M, Pla-Roca, M, Safavieh, R, Nazarova, E, Safavieh, M, Li, H (2010) Microfluidic perfusion system for culturing and imaging yeast cell microarrays and rapidly exchanging media. Lab Chip 10: pp. 2449-2457 CrossRef
  22. Parsa, H, Chin, CD, Mongkolwisetwara, P, Lee, BW, Wang, JJ, Sia, SK (2008) Effect of volume- and time-based constraints on capture of analytes in microfluidic heterogeneous immunoassays. Lab Chip 8: pp. 2062-2070 CrossRef
  23. Prat, M (2011) Pore network models of drying, contact angle, and film flows. Chem Eng Technol 34: pp. 1029-1038 CrossRef
  24. Safavieh, R, Juncker, D (2013) Capillarics: pre-programmed, self-powered microfluidic circuits built from capillary elements. Lab Chip 13: pp. 4180-4189 CrossRef
  25. Safavieh, R, Zhou, GZ, Juncker, D (2011) Microfluidics made of yarns and knots: from fundamental properties to simple networks and operations. Lab Chip 11: pp. 2618-2624 CrossRef
  26. Seebergh, JE, Berg, JC (1992) Dynamic wetting in the low capillary number regime. Chem Eng Sci 47: pp. 4455-4464 CrossRef
  27. Smith KC (1998) Introduction to electronics. In: KC鈥檚 problems and solutions for microelectronic circuits, chap 1, 4th edn, vol 1. Oxford University Press, USA, pp 1鈥?
  28. Tamayol, A, Yeom, J, Akbari, M, Bahrami, M (2013) Low Reynolds number flows across ordered arrays of micro-cylinders embedded in a rectangular micro/minichannel. Int J Heat Mass Transf 58: pp. 420-426 CrossRef
  29. Vulto, P, Podszun, S, Meyer, P, Hermann, C, Manz, A, Urban, GA (2011) Phaseguides: a paradigm shift in microfluidic priming and emptying. Lab Chip 11: pp. 1596-1602 CrossRef
  30. Weislogel MM (2003) Some analytical tools for fluids management in space: Isothermal capillary flows along interior corners. In: Narayanan R (ed) Gravitational effects in physico-chemical processes, vol 32, pp 163鈥?0
  31. Weislogel, MM, Lichter, S (1998) Capillary flow in an interior corner. J Fluid Mech 373: pp. 349-378 CrossRef
  32. White FM (2005) Solutions of the Newtonian viscous-flow equations. In: Viscous fluid flow, 3rd edn. McGraw-Hill Science/Engineering/Math, pp 116鈥?25
  33. Zimmermann, M, Schmid, H, Hunziker, P, Delamarche, E (2007) Capillary pumps for autonomous capillary systems. Lab Chip 7: pp. 119-125 CrossRef
  34. Zimmermann, M, Hunziker, P, Delamarche, E (2008) Valves for autonomous capillary systems. Microfluid Nanofluid 5: pp. 395-402 CrossRef
  
• 刊物类别：Engineering
• 刊物主题：Engineering Fluid Dynamics
  Medical Microbiology
  Polymer Sciences
  Nanotechnology
  Mechanics, Fluids and Thermodynamics
  Engineering Thermodynamics and Transport Phenomena
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1613-4990

文摘

Microfluidic capillary systems operate using capillary forces only and require capillary pumps (CPs) to transport, regulate, and meter the flow of small quantity of liquids. Common CP architectures include arrays of posts or tree-like branched conduits that offer many parallel flow paths. However, both designs are susceptible to bubble entrapment and consequently variation in the metered volume. Here, we present two novel CP architectures that deterministically guide the filling front along rows while preventing the entrapment of bubbles using variable gap sizes between posts. The first CP (serpentine pump) guides the filling front following a serpentine path, and the second one (leading-edge pump) directs the liquid along one edge of the CP from where liquid fills the pump row-by-row. We varied the angle of the rows with respect to the pump perimeter and observed filling with minimal variation in pumping pressure and volumetric flow rate, confirming the robustness of this design. In the case of serpentine CP, the flow resistance for filling the first row is high and then decreases as subsequent rows are filled and many parallel flow paths are formed. In the leading-edge pump, parallel flow paths are formed almost immediately, and hence, no spike in flow resistance is observed; however, there is a higher tendency of the liquid for skipping a row, requiring more stringent fabrication tolerances. The flow rate within a single CP was adjusted by tuning the gap size between the microposts within the CP so as to create a gradient in pressure and flow rate. In summary, CP with deterministic guidance of the filling front enables precise and robust control of flow rate and volume.