Does the capsaicin-sensitive local neural circuit constitutively regulate vagally evoked esophageal striated muscle contraction in rats?

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• 作者：Takeshi Shima ; Takahiko Shiina ; Kiyotada Naitou…
• 关键词：Capsaicin ; sensitive neuron ; Enteric neuron ; Esophagus ; Striated muscle ; Vagus
• 刊名：The Journal of Physiological Sciences
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：66
• 期：2
• 页码：105-111
• 全文大小：564 KB
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• 作者单位：Takeshi Shima (1)
  Takahiko Shiina (1)
  Kiyotada Naitou (1)
  Hiroyuki Nakamori (1)
  Yuuki Sano (1)
  Yasutake Shimizu (1)
  
  1. Laboratory of Physiology, Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan
  
• 刊物主题：Human Physiology; Neurosciences; Animal Biochemistry; Animal Physiology; Cell Physiology; Neurobiology;
• 出版者：Springer Japan
• ISSN：1880-6562

文摘

To determine whether a capsaicin-sensitive local neural circuit constitutively modulates vagal neuromuscular transmission in the esophageal striated muscle or whether the neural circuit operates in a stimulus-dependent manner, we compared the motility of esophageal preparations isolated from intact rats with those in which capsaicin-sensitive neurons had been destroyed. Electrical stimulation of the vagus nerve trunk evoked contractile responses in the esophagus isolated from a capsaicin-treated rat in a manner similar to those in the esophagus from a control rat. No obvious differences were observed in the inhibitory effects of D-tubocurarine on intact and capsaicin-treated rat esophageal motility. Destruction of the capsaicin-sensitive neurons did not significantly affect latency, time to peak and duration of a vagally evoked twitch-like contraction. These findings indicate that the capsaicin-sensitive neural circuit does not operate constitutively but rather is activated in response to an applied stimulus. Keywords Capsaicin-sensitive neuron Enteric neuron Esophagus Striated muscle Vagus