Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8

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• 作者：Masayuki Takaishi ; Kunitoshi Uchida…
• 关键词：Menthol ; Capsaicin ; TRPV1 ; TRPM8 ; Analgesic
• 刊名：The Journal of Physiological Sciences
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：66
• 期：2
• 页码：143-155
• 全文大小：1,405 KB
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• 作者单位：Masayuki Takaishi (1) (2)
  Kunitoshi Uchida (1) (3)
  Yoshiro Suzuki (1) (3)
  Hiroshi Matsui (2)
  Tadashi Shimada (2)
  Fumitaka Fujita (1) (2)
  Makoto Tominaga (1) (3)
  
  1. Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Higashiyama 5-1, Myodaiji, Okazaki, Aichi, 444-8787, Japan
  2. Mandom Corporation, Osaka, 540-8530, Japan
  3. Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, 444-8585, Japan
  
• 刊物主题：Human Physiology; Neurosciences; Animal Biochemistry; Animal Physiology; Cell Physiology; Neurobiology;
• 出版者：Springer Japan
• ISSN：1880-6562

文摘

Transient receptor potential vanilloid 1 (TRPV1) is activated by elevated temperature (>42 °C), and it has been reported that cold temperature decreases capsaicin-induced TRPV1 activity. In contrast, transient receptor potential melastatin 8 (TRPM8) is activated by low temperatures and menthol, and heat stimulation suppresses menthol-evoked TRPM8 currents. These findings suggest that the effects of specific agents on TRPV1 and TRPM8 channels are intricately interrelated. We examined the effects of menthol on human (h)TRPV1 and of capsaicin on hTRPM8. hTRPV1 currents activated by heat and capsaicin were inhibited by menthol, whereas hTRPM8 currents activated by cold and menthol were similarly inhibited by capsaicin. An in vivo sensory irritation test showed that menthol conferred an analgesic effect on the sensory irritation evoked by a capsaicin analogue. These results indicate that in our study the agonists of TRPV1 and TRPM8 interacted with both of these channels and suggest that the anti-nociceptive effects of menthol can be partially explained by this phenomenon. Keywords Menthol Capsaicin TRPV1 TRPM8 Analgesic